Please use this identifier to cite or link to this item: https://doi.org/10.1177/2047487320925965
Title: Effect of coronavirus infection on the human heart: A scoping review
Authors: Ho, Jamie SY
Tambyah, Paul A 
Ho, Andrew FW
Chan, Mark YY 
Sia, Ching-Hui 
Keywords: Science & Technology
Life Sciences & Biomedicine
Cardiac & Cardiovascular Systems
Cardiovascular System & Cardiology
Coronavirus
cardiovascular system
heart
coronavirus disease 2019
severe acute respiratory syndrome
Middle East respiratory syndrome
common cold
EAST RESPIRATORY SYNDROME
MERS-COV INFECTION
CRITICALLY-ILL PATIENTS
SAUDI-ARABIA
CLINICAL CHARACTERISTICS
SYNDROME SARS
RISK-FACTORS
HOSPITALIZED-PATIENTS
TRACT INFECTION
TERM OUTCOMES
Issue Date: 18-May-2020
Publisher: OXFORD UNIV PRESS
Citation: Ho, Jamie SY, Tambyah, Paul A, Ho, Andrew FW, Chan, Mark YY, Sia, Ching-Hui (2020-05-18). Effect of coronavirus infection on the human heart: A scoping review. EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY 27 (11) : 1136-1148. ScholarBank@NUS Repository. https://doi.org/10.1177/2047487320925965
Abstract: Background: The global coronavirus disease 2019 pandemic has highlighted the importance of understanding the cardiovascular implications of coronavirus infections, with more severe disease in those with cardiovascular co-morbidities, and resulting cardiac manifestations such as myocardial injury, arrhythmias, and heart failure. Design: A systematic review of the current knowledge on the effects of coronavirus infection on the cardiovascular system in humans was performed and results were summarized. Methods: Databases such as MEDLINE, EMBASE, CENTRAL, Scopus, Web of Science, ClinicalTrials.gov, Chinese Knowledge Resource Integrated Database and Chinese Clinical Trial Registry were searched on 20 March 2020. Results: In total, 135 studies were included, involving severe acute respiratory syndrome, Middle East respiratory syndrome, coronavirus disease 2019 and other coronaviruses. Most were case reports, case series and cohort studies of poor to fair quality. In post-mortem examinations of subjects who died from infection, around half had virus identified in heart tissues in severe acute respiratory syndrome, but none in Middle East respiratory syndrome and coronavirus disease 2019. Cardiac manifestations reported include tachycardia, bradycardia, arrhythmias, and myocardial injury, secondary to both systemic infection and treatment. Cardiac injury and arrhythmias are more prevalent in coronavirus disease 2019, and elevated cardiac markers are associated with intensive care unit admission and death. In severe acute respiratory syndrome, Middle East respiratory syndrome, and coronavirus disease 2019, comorbidities such as hypertension, diabetes mellitus, and heart disease are associated with intensive care unit admission, mechanical ventilation, and mortality. There were cases of misdiagnosis due to overlapping presentations of cardiovascular diseases and coronavirus infections, leading to hospital spread and delayed management of life-threatening conditions. Conclusion: This review highlighted the ways in which coronaviruses affect cardiovascular function and interacts with pre-existing cardiovascular diseases.
Source Title: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
URI: https://scholarbank.nus.edu.sg/handle/10635/205777
ISSN: 20474873
20474881
DOI: 10.1177/2047487320925965
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