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https://doi.org/10.1016/j.numecd.2021.03.010
| Title: | The association of genetically determined serum glycine with cardiovascular risk in East Asians | Authors: | Chang, Xuling Wang, Ling Guan, Shou Ping Kennedy, Brian K Liu, Jianjun Khor, Chiea-Chuen Low, Adrian F Chan, Mark Yan-Yee Yuan, Jian-Min Koh, Woon-Puay Friedlander, Yechiel Dorajoo, Rajkumar Heng, Chew-Kiat |
Keywords: | Genome-wide association study Circulating glycine concentration Cardiovascular risk Genetic association |
Issue Date: | 7-Jun-2021 | Publisher: | ELSEVIER SCI LTD | Citation: | Chang, Xuling, Wang, Ling, Guan, Shou Ping, Kennedy, Brian K, Liu, Jianjun, Khor, Chiea-Chuen, Low, Adrian F, Chan, Mark Yan-Yee, Yuan, Jian-Min, Koh, Woon-Puay, Friedlander, Yechiel, Dorajoo, Rajkumar, Heng, Chew-Kiat (2021-06-07). The association of genetically determined serum glycine with cardiovascular risk in East Asians. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES 31 (6) : 1840-1844. ScholarBank@NUS Repository. https://doi.org/10.1016/j.numecd.2021.03.010 | Abstract: | Background and aims: Glycine is involved in a wide range of metabolic pathways and increased circulating glycine is associated with reduced risk of cardio-metabolic diseases in Europeans but the genetic association between circulating glycine and cardiovascular risk is largely unknown in East Asians. Methods and results: We conducted a genome-wide association study (GWAS) in Singaporean Chinese participants and investigated if genetically determined serum glycine were associated with incident coronary artery disease (CAD) (711 cases and 1,246 controls), cardiovascular death (1,886 cases and 21,707 controls) and angiographic CAD severity (as determined by the Modified Gensini score, N = 1,138). Conclusion: Our study, a first in East Asians, suggest a protective role of glycine against CAD. | Source Title: | NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | URI: | https://scholarbank.nus.edu.sg/handle/10635/205761 | ISBN: | 15903729 | ISSN: | 09394753 | DOI: | 10.1016/j.numecd.2021.03.010 |
| Appears in Collections: | Staff Publications Elements |
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