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Title: One-year outcomes of patients with ST-segment elevation myocardial infarction during the COVID-19 pandemic
Authors: Phua, Kailun
Chew, Nicholas WS
Sim, Vincent
Zhang, Audrey A
Rastogi, Saurabh
Kojodjojo, Pipin 
Chor, Wei-Ping Daniel
Koh, Brandon Chi-Ping
Leong, Benjamin Sieu-Hon
Ng, Zhe-Yan
Tung, Benjamin Wei-Liang
Ambhore, Anand 
Kong, William KF
Poh, Kian-Keong 
Chai, Ping 
Ng, Gavin
Chan, Koo-Hui 
Lee, Chi-Hang 
Loh, Joshua Ping-Yun
Low, Adrian Fatt-Hoe
Chan, Mark Yan-Yee 
Yeo, Tiong-Cheng 
Tan, Huay-Cheem 
Loh, Poay-Huan 
Keywords: COVID-19
ST-elevation myocardial infarction
Primary percutaneous coronary intervention
Issue Date: 26-Aug-2021
Publisher: SPRINGER
Citation: Phua, Kailun, Chew, Nicholas WS, Sim, Vincent, Zhang, Audrey A, Rastogi, Saurabh, Kojodjojo, Pipin, Chor, Wei-Ping Daniel, Koh, Brandon Chi-Ping, Leong, Benjamin Sieu-Hon, Ng, Zhe-Yan, Tung, Benjamin Wei-Liang, Ambhore, Anand, Kong, William KF, Poh, Kian-Keong, Chai, Ping, Ng, Gavin, Chan, Koo-Hui, Lee, Chi-Hang, Loh, Joshua Ping-Yun, Low, Adrian Fatt-Hoe, Chan, Mark Yan-Yee, Yeo, Tiong-Cheng, Tan, Huay-Cheem, Loh, Poay-Huan (2021-08-26). One-year outcomes of patients with ST-segment elevation myocardial infarction during the COVID-19 pandemic. JOURNAL OF THROMBOSIS AND THROMBOLYSIS. ScholarBank@NUS Repository.
Abstract: The pandemic has led to adverse short-term outcomes for patients with ST-segment elevation myocardial infarction (STEMI). It is unknown if this translates to poorer long-term outcomes. In Singapore, the escalation of the outbreak response on February 7, 2020 demanded adaptation of STEMI care to stringent infection control measures. A total of 321 patients presenting with STEMI and undergoing primary percutaneous coronary intervention at a tertiary hospital were enrolled and followed up over 1-year. They were allocated into three groups based on admission date—(1) Before outbreak response (BOR): December 1, 2019–February 6, 2020, (2) During outbreak response (DOR): February 7–March 31, 2020, and (3) control group: November 1–December 31, 2018. The incidence of cardiac-related mortality, cardiac-related readmissions, and recurrent coronary events were examined. Although in-hospital outcomes were worse in BOR and DOR groups compared to the control group, there were no differences in the 1-year cardiac-related mortality (BOR 8.7%, DOR 7.1%, control 4.8%, p = 0.563), cardiac-related readmissions (BOR 15.1%, DOR 11.6%, control 12.0%, p = 0.693), and recurrent coronary events (BOR 3.2%, DOR 1.8%, control 1.2%, p = 0.596). There were higher rates of additional PCI during the index admission in DOR, compared to BOR and control groups (p = 0.027). While patients admitted for STEMI during the pandemic may have poorer in-hospital outcomes, their long-term outcomes remain comparable to the pre-pandemic era.
ISSN: 09295305
DOI: 10.1007/s11239-021-02557-6
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