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https://doi.org/10.1016/j.cjca.2021.04.003
Title: | The Global Effect of the COVID-19 Pandemic on STEMI Care: A Systematic Review and Meta-analysis | Authors: | Chew, NWS Ow, ZGW Teo, VXY Heng, RRY Ng, CH Lee, CH Low, AF Chan, MYY Yeo, TC Tan, HC Loh, PH |
Keywords: | COVID-19 Databases, Factual Hospital Mortality Humans Internationality Pandemics Patient Admission Percutaneous Coronary Intervention SARS-CoV-2 ST Elevation Myocardial Infarction Time Factors Time-to-Treatment Treatment Outcome |
Issue Date: | 1-Sep-2021 | Publisher: | Elsevier BV | Citation: | Chew, NWS, Ow, ZGW, Teo, VXY, Heng, RRY, Ng, CH, Lee, CH, Low, AF, Chan, MYY, Yeo, TC, Tan, HC, Loh, PH (2021-09-01). The Global Effect of the COVID-19 Pandemic on STEMI Care: A Systematic Review and Meta-analysis. Canadian Journal of Cardiology 37 (9) : 1450-1459. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cjca.2021.04.003 | Abstract: | Background: The COVID-19 pandemic has affected patients with ST-segment elevation myocardial infarction (STEMI) requiring primary percutaneous coronary intervention (PCI) worldwide. In this review we examine the global effect of the COVID-19 pandemic on incidence of STEMI admissions, and relationship between the pandemic and door to balloon time (D2B), all-cause mortality, and other secondary STEMI outcomes. Methods: We performed a systematic review and meta-analysis to primarily compare D2B time and in-hospital mortality of STEMI patients who underwent primary PCI during and before the pandemic. Subgroup analyses were performed to investigate the influence of geographical region and income status of a country on STEMI care. An online database search included studies that compared the aforementioned outcomes of STEMI patients during and before the pandemic. Results: In total, 32 articles were analyzed. Overall, 19,140 and 68,662 STEMI patients underwent primary PCI during and before the pandemic, respectively. Significant delay in D2B was observed during the pandemic (weighted mean difference, 8.10 minutes; 95% confidence interval [CI], 3.90-12.30 minutes; P = 0.0002; I2 = 90%). In-hospital mortality was higher during the pandemic (odds ratio [OR], 1.27; 95% CI, 1.09-1.49; P = 0.002; I2 = 36%), however this varied with factors such as geographical location and income status of a country. Subgroup analysis showed that low–middle-income countries observed a higher rate of mortality during the pandemic (OR, 1.52; 95% CI, 1.13-2.05; P = 0.006), with a similar but insignificant trend seen among the high income countries (OR, 1.17; 95% CI, 0.95-1.44; P = 0.13). Conclusions: The COVID-19 pandemic is associated with worse STEMI performance metrics and clinical outcome, particularly in the Eastern low–middle-income status countries. Better strategies are needed to address these global trends in STEMI care during the pandemic. | Source Title: | Canadian Journal of Cardiology | URI: | https://scholarbank.nus.edu.sg/handle/10635/205737 | ISSN: | 0828282X 19167075 |
DOI: | 10.1016/j.cjca.2021.04.003 |
Appears in Collections: | Elements Staff Publications |
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