Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.cjca.2021.04.003
Title: The Global Effect of the COVID-19 Pandemic on STEMI Care: A Systematic Review and Meta-analysis
Authors: Chew, NWS
Ow, ZGW
Teo, VXY
Heng, RRY
Ng, CH
Lee, CH 
Low, AF 
Chan, MYY 
Yeo, TC 
Tan, HC 
Loh, PH 
Keywords: COVID-19
Databases, Factual
Hospital Mortality
Humans
Internationality
Pandemics
Patient Admission
Percutaneous Coronary Intervention
SARS-CoV-2
ST Elevation Myocardial Infarction
Time Factors
Time-to-Treatment
Treatment Outcome
Issue Date: 1-Sep-2021
Publisher: Elsevier BV
Citation: Chew, NWS, Ow, ZGW, Teo, VXY, Heng, RRY, Ng, CH, Lee, CH, Low, AF, Chan, MYY, Yeo, TC, Tan, HC, Loh, PH (2021-09-01). The Global Effect of the COVID-19 Pandemic on STEMI Care: A Systematic Review and Meta-analysis. Canadian Journal of Cardiology 37 (9) : 1450-1459. ScholarBank@NUS Repository. https://doi.org/10.1016/j.cjca.2021.04.003
Abstract: Background: The COVID-19 pandemic has affected patients with ST-segment elevation myocardial infarction (STEMI) requiring primary percutaneous coronary intervention (PCI) worldwide. In this review we examine the global effect of the COVID-19 pandemic on incidence of STEMI admissions, and relationship between the pandemic and door to balloon time (D2B), all-cause mortality, and other secondary STEMI outcomes. Methods: We performed a systematic review and meta-analysis to primarily compare D2B time and in-hospital mortality of STEMI patients who underwent primary PCI during and before the pandemic. Subgroup analyses were performed to investigate the influence of geographical region and income status of a country on STEMI care. An online database search included studies that compared the aforementioned outcomes of STEMI patients during and before the pandemic. Results: In total, 32 articles were analyzed. Overall, 19,140 and 68,662 STEMI patients underwent primary PCI during and before the pandemic, respectively. Significant delay in D2B was observed during the pandemic (weighted mean difference, 8.10 minutes; 95% confidence interval [CI], 3.90-12.30 minutes; P = 0.0002; I2 = 90%). In-hospital mortality was higher during the pandemic (odds ratio [OR], 1.27; 95% CI, 1.09-1.49; P = 0.002; I2 = 36%), however this varied with factors such as geographical location and income status of a country. Subgroup analysis showed that low–middle-income countries observed a higher rate of mortality during the pandemic (OR, 1.52; 95% CI, 1.13-2.05; P = 0.006), with a similar but insignificant trend seen among the high income countries (OR, 1.17; 95% CI, 0.95-1.44; P = 0.13). Conclusions: The COVID-19 pandemic is associated with worse STEMI performance metrics and clinical outcome, particularly in the Eastern low–middle-income status countries. Better strategies are needed to address these global trends in STEMI care during the pandemic.
Source Title: Canadian Journal of Cardiology
URI: https://scholarbank.nus.edu.sg/handle/10635/205737
ISSN: 0828282X
19167075
DOI: 10.1016/j.cjca.2021.04.003
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