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https://doi.org/10.1074/jbc.M109.038539
Title: | Gata4 and Gata5 Cooperatively Regulate Cardiac Myocyte Proliferation in Mice | Authors: | Singh, Manvendra K Li, Yan Li, Shanru Cobb, Ryan M Zhou, Diane Lu, Min Min Epstein, Jonathan A Morrisey, Edward E Gruber, Peter J |
Keywords: | Science & Technology Life Sciences & Biomedicine Biochemistry & Molecular Biology CARDIOMYOCYTE CELL-CYCLE HEART TUBE FORMATION TRANSCRIPTION FACTOR GENE-EXPRESSION CARDIOVASCULAR-SYSTEM VENTRAL MORPHOGENESIS HEMATOPOIETIC-CELLS MOUSE EMBRYO DIFFERENTIATION ZEBRAFISH |
Issue Date: | 15-Jan-2010 | Publisher: | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Citation: | Singh, Manvendra K, Li, Yan, Li, Shanru, Cobb, Ryan M, Zhou, Diane, Lu, Min Min, Epstein, Jonathan A, Morrisey, Edward E, Gruber, Peter J (2010-01-15). Gata4 and Gata5 Cooperatively Regulate Cardiac Myocyte Proliferation in Mice. JOURNAL OF BIOLOGICAL CHEMISTRY 285 (3) : 1765-1772. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M109.038539 | Abstract: | GATA5 is a member of the zinc finger transcription factor GATA family (GATA1-6) that plays a wide variety of roles in embryonic and adult development. Experiments in multiple model systems have emphasized the importance of the GATA family members 4-6 in the development of the endoderm and mesoderm. Yet despite overlapping expression patterns, there is little evidence of an important role for GATA5 in mammalian cardiac development. We have generated a new Gata5 mutant allele lacking exons 2 and 3 that encodes both zinc finger domains (Gata5tm2Eem), and we show that although Gata5-/- mice are viable, Gata4+/-5-/- mutants die at mid-gestation and exhibit profound cardiovascular defects, including abnormalities of cardiomyocyte proliferation and cardiac chamber maturation. These results demonstrate functional redundancy between Gata4 and Gata5 during cardiac development and implicate Gata5 as a candidate modifier gene for congenital heart disease. © 2010 by The American Society for Biochemistry and Molecular Biology, Inc. | Source Title: | JOURNAL OF BIOLOGICAL CHEMISTRY | URI: | https://scholarbank.nus.edu.sg/handle/10635/201349 | ISSN: | 00219258 1083351X |
DOI: | 10.1074/jbc.M109.038539 |
Appears in Collections: | Staff Publications Elements |
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2010. Singh et al. Journal of Biological Chemistry.pdf | Published version | 3.28 MB | Adobe PDF | OPEN | None | View/Download |
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