Please use this identifier to cite or link to this item: https://doi.org/10.1074/jbc.M109.038539
Title: Gata4 and Gata5 Cooperatively Regulate Cardiac Myocyte Proliferation in Mice
Authors: Singh, Manvendra K 
Li, Yan
Li, Shanru
Cobb, Ryan M
Zhou, Diane
Lu, Min Min 
Epstein, Jonathan A
Morrisey, Edward E
Gruber, Peter J
Keywords: Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
CARDIOMYOCYTE CELL-CYCLE
HEART TUBE FORMATION
TRANSCRIPTION FACTOR
GENE-EXPRESSION
CARDIOVASCULAR-SYSTEM
VENTRAL MORPHOGENESIS
HEMATOPOIETIC-CELLS
MOUSE EMBRYO
DIFFERENTIATION
ZEBRAFISH
Issue Date: 15-Jan-2010
Publisher: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Citation: Singh, Manvendra K, Li, Yan, Li, Shanru, Cobb, Ryan M, Zhou, Diane, Lu, Min Min, Epstein, Jonathan A, Morrisey, Edward E, Gruber, Peter J (2010-01-15). Gata4 and Gata5 Cooperatively Regulate Cardiac Myocyte Proliferation in Mice. JOURNAL OF BIOLOGICAL CHEMISTRY 285 (3) : 1765-1772. ScholarBank@NUS Repository. https://doi.org/10.1074/jbc.M109.038539
Abstract: GATA5 is a member of the zinc finger transcription factor GATA family (GATA1-6) that plays a wide variety of roles in embryonic and adult development. Experiments in multiple model systems have emphasized the importance of the GATA family members 4-6 in the development of the endoderm and mesoderm. Yet despite overlapping expression patterns, there is little evidence of an important role for GATA5 in mammalian cardiac development. We have generated a new Gata5 mutant allele lacking exons 2 and 3 that encodes both zinc finger domains (Gata5tm2Eem), and we show that although Gata5-/- mice are viable, Gata4+/-5-/- mutants die at mid-gestation and exhibit profound cardiovascular defects, including abnormalities of cardiomyocyte proliferation and cardiac chamber maturation. These results demonstrate functional redundancy between Gata4 and Gata5 during cardiac development and implicate Gata5 as a candidate modifier gene for congenital heart disease. © 2010 by The American Society for Biochemistry and Molecular Biology, Inc.
Source Title: JOURNAL OF BIOLOGICAL CHEMISTRY
URI: https://scholarbank.nus.edu.sg/handle/10635/201349
ISSN: 00219258
1083351X
DOI: 10.1074/jbc.M109.038539
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