Please use this identifier to cite or link to this item: https://doi.org/10.1111/cpr.12877
Title: microRNA exchange via extracellular vesicles in cancer
Authors: Vu, L.T.
Gong, J.
Pham, T.T.
Kim, Y.
Le, M.T.N. 
Keywords: cancer biology
extracellular vesicles
microRNAs
tumour microenvironment
Issue Date: 2020
Publisher: Blackwell Publishing Ltd
Citation: Vu, L.T., Gong, J., Pham, T.T., Kim, Y., Le, M.T.N. (2020). microRNA exchange via extracellular vesicles in cancer. Cell Proliferation 53 (11) : e12877. ScholarBank@NUS Repository. https://doi.org/10.1111/cpr.12877
Rights: Attribution 4.0 International
Abstract: Cells utilize different means of inter-cellular communication to function properly. Here, we review the crosstalk between cancer cells and their surrounding environment through microRNA (miRNA)-containing extracellular vesicles (EVs). The current findings suggest that the export of miRNAs and uptake of miRNA-containing EVs might be an active process. As post-transcriptional regulators of gene expression, cancer-derived miRNAs that are taken up by normal cells can change the translational profile of the recipient cell towards a transformed proteome. Stromal cells can also deliver miRNAs via EVs to cancer cells to support tumour growth and cancer progression. Therefore, gaining a better understanding of EV-mediated inter-cellular communication in the tumour microenvironment might lead to the development of novel diagnostic and therapeutic strategies. © 2020 The Authors. Cell Proliferation Published by John Wiley & Sons Ltd.
Source Title: Cell Proliferation
URI: https://scholarbank.nus.edu.sg/handle/10635/199681
ISSN: 0960-7722
DOI: 10.1111/cpr.12877
Rights: Attribution 4.0 International
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