Please use this identifier to cite or link to this item: https://doi.org/10.1172/jci.insight.135681
Title: Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10
Authors: Camacho, V.
Matkins, V.R.
Patel, S.B.
Lever, J.M.
Yang, Z.
Ying, L. 
Landuyt, A.E.
Dean, E.C.
George, J.F.
Yang, H.
Ferrell, P.B.
Maynard, C.L.
Weaver, C.T.
Turnquist, H.R.
Welner, R.S.
Issue Date: 2020
Publisher: American Society for Clinical Investigation
Citation: Camacho, V., Matkins, V.R., Patel, S.B., Lever, J.M., Yang, Z., Ying, L., Landuyt, A.E., Dean, E.C., George, J.F., Yang, H., Ferrell, P.B., Maynard, C.L., Weaver, C.T., Turnquist, H.R., Welner, R.S. (2020). Bone marrow Tregs mediate stromal cell function and support hematopoiesis via IL-10. JCI Insight 5 (22) : e135681. ScholarBank@NUS Repository. https://doi.org/10.1172/jci.insight.135681
Rights: Attribution 4.0 International
Abstract: The nonimmune roles of Tregs have been described in various tissues, including the BM. In this study, we comprehensively phenotyped marrow Tregs, elucidating their key features and tissue-specific functions. We show that marrow Tregs are migratory and home back to the marrow. For trafficking, marrow Tregs use S1P gradients, and disruption of this axis allows for specific targeting of the marrow Treg pool. Following Treg depletion, the function and phenotype of both mesenchymal stromal cells (MSCs) and hematopoietic stem cells (HSCs) was impaired. Transplantation also revealed that a Treg-depleted niche has a reduced capacity to support hematopoiesis. Finally, we found that marrow Tregs are high producers of IL-10 and that Treg-secreted IL-10 has direct effects on MSC function. This is the first report to our knowledge revealing that Treg-secreted IL-10 is necessary for stromal cell maintenance, and our work outlines an alternative mechanism by which this cytokine regulates hematopoiesis. : © 2020, Camacho et al.
Source Title: JCI Insight
URI: https://scholarbank.nus.edu.sg/handle/10635/199378
ISSN: 23793708
DOI: 10.1172/jci.insight.135681
Rights: Attribution 4.0 International
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