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https://doi.org/10.1016/j.diabres.2021.108978
Title: | Maternal height, gestational diabetes mellitus and pregnancy complications | Authors: | Chu A.H.Y. Yuan W.L. Loy S.L. Soh S.E. Bernard J.Y. Tint M.-T. Ho-Lim S.S.T. Goh H. Ramasamy A. Kumar M. Goh C. Ang L.T. Shek L.P.-C. Chong Y.S. Tan K.H. Su L.L. Biswas A. Yap F. Lee Y.S. Chi C. Godfrey K.M. Eriksson J.G. Chan S.-Y. |
Keywords: | Blood glucose Cohort study Gestational diabetes mellitus Glucose tolerance test Pregnancy complications Standing height |
Issue Date: | Aug-2021 | Publisher: | Elsevier Ireland Ltd | Citation: | Chu A.H.Y., Yuan W.L., Loy S.L., Soh S.E., Bernard J.Y., Tint M.-T., Ho-Lim S.S.T., Goh H., Ramasamy A., Kumar M., Goh C., Ang L.T., Shek L.P.-C., Chong Y.S., Tan K.H., Su L.L., Biswas A., Yap F., Lee Y.S., Chi C., Godfrey K.M., Eriksson J.G., Chan S.-Y. (2021-08). Maternal height, gestational diabetes mellitus and pregnancy complications. Diabetes Research and Clinical Practice 178. ScholarBank@NUS Repository. https://doi.org/10.1016/j.diabres.2021.108978 | Abstract: | Aims: To explore the glucose-overload hypothesis of artefactual gestational diabetes (GDM) diagnosis in shorter women during oral glucose tolerance testing (OGTT), by investigating associations between height and maternal glycemia; and GDM and pregnancy complications in height-groups. Methods: Women from GUSTO (n = 1100, 2009–2010) and NUH (n = 4068, 2017–2018) cohorts underwent a mid-gestation two and three time-point 75 g 2-hour OGTT, respectively. GDM-related complications (hypertensive disorders of pregnancy, preterm delivery, emergency cesarean section, neonatal intensive care unit admission, macrosomia, birthweight) were compared within shorter and taller groups, dichotomized by ethnic-specific median height. Results: Using WHO-1999 criteria, 18.8% (GUSTO) to 22.9% (NUH) of women were diagnosed with GDM-1999; and by WHO-2013 criteria, 21.9% (NUH) had GDM-2013. Each 5-cm height increment was inversely associated with GDM-1999 (adjusted odds ratio [aOR, 95% CI] = 0.81 [0.76–0.87], 2-h glycemia (adjusted β [aβ, 95% CI] = -0.171 mmol/L [-0.208, -0.135]) and 1-h glycemia (aβ = -0.160 mmol/L [-0.207, -0.112]). The inverse association between height and 2-h glycemia was most marked in “Other” ethnicities (Eurasians/Caucasians/mixed/other Asians) and Indians, followed by Chinese, then Malays. Compared with non-GDM, GDM-1999 was associated with preterm delivery (aOR = 1.76 [1.19–2.61]) and higher birthweight (aβ = 57.16 g [20.95, 93.38]) only among taller but not shorter women. Conclusions: Only taller women had an increased odds of GDM-related pregnancy complications. An artefactual GDM diagnosis due to glucose-overload among shorter women is plausible. | Source Title: | Diabetes Research and Clinical Practice | URI: | https://scholarbank.nus.edu.sg/handle/10635/198831 | ISSN: | 01688227 | DOI: | 10.1016/j.diabres.2021.108978 |
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MainDoc_Height_GDM_DRCP_revised_22Jun.pdf | 247.39 kB | Adobe PDF | OPEN | Post-print | View/Download | |
Supplementary Figure S1_Study Flow Chart.pdf | 9.87 kB | Adobe PDF | OPEN | Post-print | View/Download | |
Supplementary Table S1.pdf | 40.58 kB | Adobe PDF | OPEN | Post-print | View/Download | |
Supplementary Table S2.pdf | 32.05 kB | Adobe PDF | OPEN | Post-print | View/Download | |
Supplementary Table S3.pdf | 16.08 kB | Adobe PDF | OPEN | Post-print | View/Download | |
Supplementary Table S4.pdf | 80.18 kB | Adobe PDF | OPEN | Post-print | View/Download | |
Fig_1_1Apr.pdf | 85.22 kB | Adobe PDF | OPEN | Post-print | View/Download | |
Fig_2_1Apr.pdf | 260.92 kB | Adobe PDF | OPEN | Post-print | View/Download | |
Supplementary Figure S2.pdf | 1.34 MB | Adobe PDF | OPEN | Post-print | View/Download | |
Supplementary Figure S3.pdf | 1.78 MB | Adobe PDF | OPEN | Post-print | View/Download |
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