Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.diabres.2021.108978
Title: Maternal height, gestational diabetes mellitus and pregnancy complications
Authors: Chu A.H.Y.
Yuan W.L. 
Loy S.L. 
Soh S.E. 
Bernard J.Y.
Tint M.-T. 
Ho-Lim S.S.T.
Goh H.
Ramasamy A.
Kumar M.
Goh C.
Ang L.T.
Shek L.P.-C. 
Chong Y.S. 
Tan K.H. 
Su L.L. 
Biswas A. 
Yap F. 
Lee Y.S. 
Chi C. 
Godfrey K.M.
Eriksson J.G. 
Chan S.-Y. 
Keywords: Blood glucose
Cohort study
Gestational diabetes mellitus
Glucose tolerance test
Pregnancy complications
Standing height
Issue Date: Aug-2021
Publisher: Elsevier Ireland Ltd
Citation: Chu A.H.Y., Yuan W.L., Loy S.L., Soh S.E., Bernard J.Y., Tint M.-T., Ho-Lim S.S.T., Goh H., Ramasamy A., Kumar M., Goh C., Ang L.T., Shek L.P.-C., Chong Y.S., Tan K.H., Su L.L., Biswas A., Yap F., Lee Y.S., Chi C., Godfrey K.M., Eriksson J.G., Chan S.-Y. (2021-08). Maternal height, gestational diabetes mellitus and pregnancy complications. Diabetes Research and Clinical Practice 178. ScholarBank@NUS Repository. https://doi.org/10.1016/j.diabres.2021.108978
Abstract: Aims: To explore the glucose-overload hypothesis of artefactual gestational diabetes (GDM) diagnosis in shorter women during oral glucose tolerance testing (OGTT), by investigating associations between height and maternal glycemia; and GDM and pregnancy complications in height-groups. Methods: Women from GUSTO (n = 1100, 2009–2010) and NUH (n = 4068, 2017–2018) cohorts underwent a mid-gestation two and three time-point 75 g 2-hour OGTT, respectively. GDM-related complications (hypertensive disorders of pregnancy, preterm delivery, emergency cesarean section, neonatal intensive care unit admission, macrosomia, birthweight) were compared within shorter and taller groups, dichotomized by ethnic-specific median height. Results: Using WHO-1999 criteria, 18.8% (GUSTO) to 22.9% (NUH) of women were diagnosed with GDM-1999; and by WHO-2013 criteria, 21.9% (NUH) had GDM-2013. Each 5-cm height increment was inversely associated with GDM-1999 (adjusted odds ratio [aOR, 95% CI] = 0.81 [0.76–0.87], 2-h glycemia (adjusted β [aβ, 95% CI] = -0.171 mmol/L [-0.208, -0.135]) and 1-h glycemia (aβ = -0.160 mmol/L [-0.207, -0.112]). The inverse association between height and 2-h glycemia was most marked in “Other” ethnicities (Eurasians/Caucasians/mixed/other Asians) and Indians, followed by Chinese, then Malays. Compared with non-GDM, GDM-1999 was associated with preterm delivery (aOR = 1.76 [1.19–2.61]) and higher birthweight (aβ = 57.16 g [20.95, 93.38]) only among taller but not shorter women. Conclusions: Only taller women had an increased odds of GDM-related pregnancy complications. An artefactual GDM diagnosis due to glucose-overload among shorter women is plausible.
Source Title: Diabetes Research and Clinical Practice
URI: https://scholarbank.nus.edu.sg/handle/10635/198831
ISSN: 01688227
DOI: 10.1016/j.diabres.2021.108978
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