Bioresorbable polymeric scaffold in cardiovascular applications
Toong, D.W.Y. Toh, H.W. Ng, J.C.K. Wong, P.E.H. Leo, H.L. Venkatraman, S. Tan, L.P. Ang, H.Y. Huang, Y.
Toong, D.W.Y.
Toh, H.W.
Tan, L.P.
Huang, Y.
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Alternative Title
Abstract
Advances in material science and innovative medical technologies have allowed the development of less invasive interventional procedures for deploying implant devices, including scaffolds for cardiac tissue engineering. Biodegradable materials (e.g., resorbable polymers) are employed in devices that are only needed for a transient period. In the case of coronary stents, the device is only required for 6–8 months before positive remodelling takes place. Hence, biodegradable polymeric stents have been considered to promote this positive remodelling and eliminate the issue of permanent caging of the vessel. In tissue engineering, the role of the scaffold is to support favourable cell-scaffold interaction to stimulate formation of functional tissue. The ideal outcome is for the cells to produce their own extracellular matrix over time and eventually replace the implanted scaffold or tissue engineered construct. Synthetic biodegradable polymers are the favoured candidates as scaffolds, because their degradation rates can be manipulated over a broad time scale, and they may be functionalised easily. This review presents an overview of coronary heart disease, the limitations of current interventions and how biomaterials can be used to potentially circumvent these shortcomings in bioresorbable stents, vascular grafts and cardiac patches. The material specifications, type of polymers used, current progress and future challenges for each application will be discussed in this manuscript. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Keywords
Biomaterials, Bioresorbable scaffolds, Cardiac patches, Cardiovascular tissue engineering, Polymeric scaffolds, Vascular grafts
Source Title
International Journal of Molecular Sciences
Publisher
MDPI AG
Series/Report No.
Collections
Rights
Attribution 4.0 International
Date
2020-05-13
DOI
10.3390/ijms21103444
Type
Review