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Title: Targeting metabolism in cancer cells and the tumour microenvironment for cancer therapy
Authors: Li, J.
Eu, J.Q. 
Kong, L.R. 
Wang, L. 
Lim, Y.C. 
Goh, B.C. 
Wong, A.L.A. 
Keywords: Cancer cell metabolism
Metabolic reprogramming
Targeted therapy
Tumour microenvironment
Issue Date: 20-Oct-2020
Publisher: MDPI AG
Citation: Li, J., Eu, J.Q., Kong, L.R., Wang, L., Lim, Y.C., Goh, B.C., Wong, A.L.A. (2020-10-20). Targeting metabolism in cancer cells and the tumour microenvironment for cancer therapy. Molecules 25 (20) : 4831. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Targeting altered tumour metabolism is an emerging therapeutic strategy for cancer treatment. The metabolic reprogramming that accompanies the development of malignancy creates targetable differences between cancer cells and normal cells, which may be exploited for therapy. There is also emerging evidence regarding the role of stromal components, creating an intricate metabolic network consisting of cancer cells, cancer-associated fibroblasts, endothelial cells, immune cells, and cancer stem cells. This metabolic rewiring and crosstalk with the tumour microenvironment play a key role in cell proliferation, metastasis, and the development of treatment resistance. In this review, we will discuss therapeutic opportunities, which arise from dysregulated metabolism and metabolic crosstalk, highlighting strategies that may aid in the precision targeting of altered tumour metabolism with a focus on combinatorial therapeutic strategies. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Molecules
ISSN: 14203049
DOI: 10.3390/molecules25204831
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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