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Title: The Role of Single-Cell Technology in the Study and Control of Infectious Diseases
Authors: Lin, W.N. 
Tay, M.Z.
Lu, R.
Liu, Y. 
Chen, C.-H.
Cheow, L.F. 
Keywords: diagnostics
infectious disease
single cell
Issue Date: 10-Jun-2020
Publisher: NLM (Medline)
Citation: Lin, W.N., Tay, M.Z., Lu, R., Liu, Y., Chen, C.-H., Cheow, L.F. (2020-06-10). The Role of Single-Cell Technology in the Study and Control of Infectious Diseases. Cells 9 (6). ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: The advent of single-cell research in the recent decade has allowed biological studies at an unprecedented resolution and scale. In particular, single-cell analysis techniques such as Next-Generation Sequencing (NGS) and Fluorescence-Activated Cell Sorting (FACS) have helped show substantial links between cellular heterogeneity and infectious disease progression. The extensive characterization of genomic and phenotypic biomarkers, in addition to host-pathogen interactions at the single-cell level, has resulted in the discovery of previously unknown infection mechanisms as well as potential treatment options. In this article, we review the various single-cell technologies and their applications in the ongoing fight against infectious diseases, as well as discuss the potential opportunities for future development.
Source Title: Cells
ISSN: 20734409
DOI: 10.3390/cells9061440
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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