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Title: A prediction tool for the presence of ceftriaxone-resistant uropathogens upon hospital admission
Authors: Li, N.Y.
Poh, G.Q.
Teng, G.C.W.
Chen, H.H.
Chan, D.S.G.
Chan, S.-P. 
Tambyah, P.A. 
Bagdasarian, Natasha 
Wu, J.E.
Keywords: Antibiotic resistance
Prediction tool
Urinary tract infection
Issue Date: 2020
Publisher: MDPI AG
Citation: Li, N.Y., Poh, G.Q., Teng, G.C.W., Chen, H.H., Chan, D.S.G., Chan, S.-P., Tambyah, P.A., Bagdasarian, Natasha, Wu, J.E. (2020). A prediction tool for the presence of ceftriaxone-resistant uropathogens upon hospital admission. Antibiotics 9 (6) : 1-Sep. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Antimicrobial resistance among uropathogens is a particularly pressing problem in the Asia-Pacific region. The objectives of this study were to determine the incidence and susceptibility of uropathogens upon hospital admission and to develop a risk-scoring model to predict the presence of ceftriaxone-resistance uropathogens (CrP). This was a retrospective observational cohort study of patients with a positive urine culture within 48 h of presentation at National University Hospital, Singapore between June 2015 and August 2015. Escherichia coli was the most common uropathogen isolated (51.7%), followed by Klebsiella pneumonia (15.1%) and Pseudomonas aeruginosa (8.2%). Overall, 372 out of 869 isolates (42.8%) were resistant to ceftriaxone. Hospitalization for ?2 days within past 30 days, antibiotic use within the past 3 months and male gender were associated with the presence of CrP. A risk score based on these parameters successfully predicted CrP with an area under the curve of 0.68. The risk score will help clinicians to accurately predict antibiotic resistance at the individual patient level and allow physicians to safely prescribe empiric ceftriaxone in patients at low risk of CrP, thus reducing the antibiotic selection pressure that is driving carbapenem resistance in hospitals throughout Asia. � 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Antibiotics
ISSN: 20796382
DOI: 10.3390/antibiotics9060316
Rights: Attribution 4.0 International
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