Please use this identifier to cite or link to this item: https://doi.org/10.3390/nu12092622
Title: Association of weight loss from early to middle adulthood and incident hypertension risk later in life
Authors: Zhou, Y.
Wang, T.
Yin, X.
Sun, Y.
Seow, W.J. 
Keywords: Body mass index
Cohort study
Hypertension
Issue Date: 2020
Publisher: MDPI AG
Citation: Zhou, Y., Wang, T., Yin, X., Sun, Y., Seow, W.J. (2020). Association of weight loss from early to middle adulthood and incident hypertension risk later in life. Nutrients 12 (9) : 1-12. ScholarBank@NUS Repository. https://doi.org/10.3390/nu12092622
Rights: Attribution 4.0 International
Abstract: Background: The effect of obesity in early adulthood and weight loss on incident hypertension in older age has not been well characterized. This study aimed to examine the association of weight loss from young adulthood to midlife with risk of incident hypertension later in life. Methods: We performed a retrospective cohort study using data from the National Health and Nutrition Examination Survey (NHANES). Five weight change groups were categorized: stable normal, weight loss, weight gain, maximum overweight and stable obese. The hazard ratios (HRs) and 95% confidence intervals (CIs) of the association between weight change and risk of hypertension in later life were estimated using Cox regression models. Results: Compared with participants who maintained normal weight, the stable obese, weight gain, maximum overweight and weight loss groups exhibited significantly higher risks of incident hypertension, with HR of 3.28 (95% CI = 2.71 to 3.96), 2.93 (95% CI = 2.62 to 3.28), 1.76 (95% CI = 1.55 to 2.00) and 1.97 (95% CI = 1.17 to 3.31), respectively. We also observed a lower risk among those in the weight loss group (HR = 0.60, 95% CI = 0.35 to 1.02) compared with those who were stable obese. Conclusions: Weight loss from early to middle adulthood was associated with lower risk of incident hypertension as compared to those who stayed obese and higher risk of incident hypertension as compared to those who maintained normal weight. Thus, maintaining normal weight throughout adulthood may be important for the primary prevention of hypertension. © 2020 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: Nutrients
URI: https://scholarbank.nus.edu.sg/handle/10635/197577
ISSN: 20726643
DOI: 10.3390/nu12092622
Rights: Attribution 4.0 International
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