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Title: Validation study of hla-b* 13:01 as a biomarker of dapsone hypersensitivity syndrome in leprosy patients in Indonesia
Authors: Krismawati, H.
Irwanto, A. 
Pongtiku, A.
Irwan, I.D.
Maladan, Y.
Sitanggang, Y.A.
Wahyuni, T.
Tanjung, R.
Sun, Y.
Liu, H.
Zhang, F.
Oktavian, A.
Liu, J. 
Issue Date: 2020
Publisher: Public Library of Science
Citation: Krismawati, H., Irwanto, A., Pongtiku, A., Irwan, I.D., Maladan, Y., Sitanggang, Y.A., Wahyuni, T., Tanjung, R., Sun, Y., Liu, H., Zhang, F., Oktavian, A., Liu, J. (2020). Validation study of hla-b* 13:01 as a biomarker of dapsone hypersensitivity syndrome in leprosy patients in Indonesia. PLoS Neglected Tropical Diseases 14 (10) : 1-11. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Leprosy is a stigmatizing, chronic infection which degenerates the nervous system and often leads to incapacitation. Multi-drug therapy which consists of dapsone, rifampicin and clofazimine has been effective to combat this disease. In Indonesia, especially in Papua Island, leprosy is still a problem. Furthermore, there had been higher reports of Dapsone Hypersensitivity Syndrome (DHS) which also challenges leprosy elimination in certain aspects. Globally, DHS has a prevalence rate of 1.4% and a fatality rate up to 13%. The aim of this study is to validate HLA-B*13:01, a previously discovered biomarker for DHS in the Chinese population, as a biomarker for DHS in the Papua population.This is a case-control study of 34 leprosy patients who presented themselves with DHS (case subjects) and 52 leprosy patients without DHS (control subjects). Patients were recruited from 2 provinces: Papua and West Papua. DNA was extracted from 3 ml blood specimens. HLA-B alleles were typed using the gold-standard sequence based typing method. Results were then ana-lysed using logistic regression and risk assessment was carried out. The results of HLA-typ-ing showed that HLA-B*13:01 was the most significant allele associated with DHS, with odds ratio = 233.64 and P-value = 7.11×10?9, confirming the strong association of HLA-B*13:01 to DHS in the Papua population. The sensitivity of this biomarker is 91.2% and specificity is 96.2%, with an area under the curve of 0.95. HLA-B*13:01 is validated as a bio-marker for DHS in leprosy patients in Papua, Indonesia, and can potentially be a good pre-dictor of DHS to help prevent this condition in the future. © 2020 Krismawati et al.
Source Title: PLoS Neglected Tropical Diseases
ISSN: 19352727
DOI: 10.1371/journal.pntd.0008746
Rights: Attribution 4.0 International
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