Please use this identifier to cite or link to this item: https://doi.org/10.3389/fimmu.2020.00287
Title: Role of T Cells in Chikungunya Virus Infection and Utilizing Their Potential in Anti-Viral Immunity
Authors: Poh, C.M.
Chan, Y.-H.
Ng, L.F.P. 
Keywords: chikungunya
immunopathology
resident-memory T cells
T cells
vaccination
Issue Date: 2020
Publisher: Frontiers Media S.A.
Citation: Poh, C.M., Chan, Y.-H., Ng, L.F.P. (2020). Role of T Cells in Chikungunya Virus Infection and Utilizing Their Potential in Anti-Viral Immunity. Frontiers in Immunology 11 : 287. ScholarBank@NUS Repository. https://doi.org/10.3389/fimmu.2020.00287
Rights: Attribution 4.0 International
Abstract: Chikungunya virus (CHIKV) is an arthropod-borne alphavirus that causes hallmark debilitating polyarthralgia, fever, and rash in patients. T cell-mediated immunity, especially CD4+ T cells, are known to participate in the pathogenic role of CHIKV immunopathology. The other T cell subsets, notably CD8+, NKT, and gamma-delta (??) T cells, can also contribute to protective immunity, but their effect is not actuated during the natural course of infection. This review serves to consolidate and discuss the multifaceted roles of these T cell subsets during acute and chronic phases of CHIKV infection, and highlight gaps in the current literature. Importantly, the unique characteristics of skin-resident memory T cells are outlined to propose novel prophylactic strategies that utilize their properties to provide adequate, lasting protection. © Copyright © 2020 Poh, Chan and Ng.
Source Title: Frontiers in Immunology
URI: https://scholarbank.nus.edu.sg/handle/10635/196799
ISSN: 16643224
DOI: 10.3389/fimmu.2020.00287
Rights: Attribution 4.0 International
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