Please use this identifier to cite or link to this item: https://doi.org/10.3389/fimmu.2020.00287
DC FieldValue
dc.titleRole of T Cells in Chikungunya Virus Infection and Utilizing Their Potential in Anti-Viral Immunity
dc.contributor.authorPoh, C.M.
dc.contributor.authorChan, Y.-H.
dc.contributor.authorNg, L.F.P.
dc.date.accessioned2021-08-13T02:54:01Z
dc.date.available2021-08-13T02:54:01Z
dc.date.issued2020
dc.identifier.citationPoh, C.M., Chan, Y.-H., Ng, L.F.P. (2020). Role of T Cells in Chikungunya Virus Infection and Utilizing Their Potential in Anti-Viral Immunity. Frontiers in Immunology 11 : 287. ScholarBank@NUS Repository. https://doi.org/10.3389/fimmu.2020.00287
dc.identifier.issn16643224
dc.identifier.urihttps://scholarbank.nus.edu.sg/handle/10635/196799
dc.description.abstractChikungunya virus (CHIKV) is an arthropod-borne alphavirus that causes hallmark debilitating polyarthralgia, fever, and rash in patients. T cell-mediated immunity, especially CD4+ T cells, are known to participate in the pathogenic role of CHIKV immunopathology. The other T cell subsets, notably CD8+, NKT, and gamma-delta (??) T cells, can also contribute to protective immunity, but their effect is not actuated during the natural course of infection. This review serves to consolidate and discuss the multifaceted roles of these T cell subsets during acute and chronic phases of CHIKV infection, and highlight gaps in the current literature. Importantly, the unique characteristics of skin-resident memory T cells are outlined to propose novel prophylactic strategies that utilize their properties to provide adequate, lasting protection. © Copyright © 2020 Poh, Chan and Ng.
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScopus OA2020
dc.subjectchikungunya
dc.subjectimmunopathology
dc.subjectresident-memory T cells
dc.subjectT cells
dc.subjectvaccination
dc.typeArticle
dc.contributor.departmentBIOCHEMISTRY
dc.description.doi10.3389/fimmu.2020.00287
dc.description.sourcetitleFrontiers in Immunology
dc.description.volume11
dc.description.page287
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