Please use this identifier to cite or link to this item: https://doi.org/10.1111/acel.13305
Title: Age-related changes in hippocampal-dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor
Authors: WONG LIK WEI 
CARLOS F. IBANEZ 
SAJI KUMAR SREEDHARAN 
KISISWA, LILIAN 
SIM WEILING EUNICE 
Issue Date: 1-Feb-2021
Citation: WONG LIK WEI, CARLOS F. IBANEZ, SAJI KUMAR SREEDHARAN, KISISWA, LILIAN, SIM WEILING EUNICE (2021-02-01). Age-related changes in hippocampal-dependent synaptic plasticity and memory mediated by p75 neurotrophin receptor. Aging Cell 20 (2) : e13305. ScholarBank@NUS Repository. https://doi.org/10.1111/acel.13305
Rights: CC0 1.0 Universal
Abstract: The plasticity mechanisms in the nervous system that are important for learning and memory are greatly impacted during aging. Notably, hippocampal-dependent long-term plasticity and its associative plasticity, such as synaptic tagging and capture (STC), show considerable age-related decline. The p75 neurotrophin receptor (p75NTR) is a negative regulator of structural and functional plasticity in the brain and thus represents a potential candidate to mediate age-related alterations. However, the mechanisms by which p75NTR affects synaptic plasticity of aged neuronal networks and ultimately contribute to deficits in cognitive function have not been well characterized. Here, we report that mutant mice lacking the p75NTR were resistant to age-associated changes in long-term plasticity, associative plasticity, and associative memory. Our study shows that p75NTR is responsible for age-dependent disruption of hippocampal homeostatic plasticity by modulating several signaling pathways, including BDNF, MAPK, Arc, and RhoA-ROCK2-LIMK1-cofilin. p75NTR may thus represent an important therapeutic target for limiting the age-related memory and cognitive function deficits. © 2021 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.
Source Title: Aging Cell
URI: https://scholarbank.nus.edu.sg/handle/10635/191505
ISSN: 14749718
DOI: 10.1111/acel.13305
Rights: CC0 1.0 Universal
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
AC03DF70-0A9D-4172-A63B-2E4FDC88EBFC.pdf3.55 MBAdobe PDF

OPEN

PublishedView/Download

SCOPUSTM   
Citations

7
checked on May 20, 2022

Page view(s)

103
checked on May 12, 2022

Download(s)

3
checked on May 12, 2022

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons