Please use this identifier to cite or link to this item: https://doi.org/10.1038/s41390-020-01356-8
Title: Echocardiographic assessment of fetal cardiac function in the uterine artery ligation rat model of IUGR
Authors: Dai, Y 
Zhao, D
Chen, CK 
Yap, CH
Issue Date: 1-Jan-2021
Publisher: Springer Science and Business Media LLC
Citation: Dai, Y, Zhao, D, Chen, CK, Yap, CH (2021-01-01). Echocardiographic assessment of fetal cardiac function in the uterine artery ligation rat model of IUGR. Pediatric Research. ScholarBank@NUS Repository. https://doi.org/10.1038/s41390-020-01356-8
Abstract: Background: Intrauterine growth restriction (IUGR) leads to cardiac dysfunction and adverse remodeling of the fetal heart, as well as a higher risk of postnatal cardiovascular diseases. The rat model of IUGR, via uterine artery ligation, is a popular model but its cardiac sequelae is not well investigated. Here, we performed an echocardiographic evaluation of its cardiac function to determine how well it can represent the disease in humans. Methods: Unilateral uterine artery ligation was performed at embryonic day 17 (E17) and echocardiography was performed at E19 and E20. Results: Growth-restricted fetuses were significantly smaller and lighter, and had an higher placenta-to-fetus weight ratio. Growth-restricted fetal hearts had reduced wall thickness-to-diameter ratio, indicating left ventricular (LV) dilatation, and they had elevated trans-mitral and trans-tricuspid E/A ratios and reduced left and right ventricular fractional shortening (FS), suggesting systolic and diastolic dysfunction. These were similar to human IUGR fetuses. However, growth-restricted rat fetuses did not demonstrate head-sparing effect, displayed a lower LV myocardial performance index, and ventricular outflow velocities were not significantly reduced, which were dissimilar to human IUGR fetuses. Conclusions: Despite the differences, our results suggest that this IUGR model has significant cardiac dysfunction, and could be a suitable model for studying IUGR cardiovascular physiology. Impact: Animal models of IUGR are useful, but their fetal cardiac function is not well studied, and it is unclear if they can represent human IUGR fetuses.We performed an echocardiographic assessment of the heart function of a fetal rat model of IUGR, created via maternal uterine artery ligation.Similar to humans, the model displayed LV dilatation, elevated E/A ratios, and reduced FS.Different from humans, the model displayed reduced MPI, and no significant outflow velocity reduction.Despite differences with humans, this rat model still displayed cardiac dysfunction and is suitable for studying IUGR cardiovascular physiology.
Source Title: Pediatric Research
URI: https://scholarbank.nus.edu.sg/handle/10635/191449
ISSN: 00313998
15300447
DOI: 10.1038/s41390-020-01356-8
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
PedRes2021_Echocardiographic assessment of fetal cardiac function in the uterine artery ligation rat model of IUGR.pdfPublished version742.08 kBAdobe PDF

OPEN

PublishedView/Download

Page view(s)

107
checked on May 12, 2022

Download(s)

1
checked on May 12, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.