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https://doi.org/10.1016/j.redox.2018.11.014
Title: | Redox regulation of cell state and fate | Authors: | Lee, BWL PRAMILA BABAN GHODE ONG SEK TONG, DERRICK |
Keywords: | Cancer stem cells Epigenetics Metabolism Reactive oxygen species Therapeutics Carcinogenesis Cell Lineage Epigenesis, Genetic Humans Neoplastic Stem Cells Oxidation-Reduction Reactive Oxygen Species |
Issue Date: | 1-Jul-2019 | Publisher: | Elsevier BV | Citation: | Lee, BWL, PRAMILA BABAN GHODE, ONG SEK TONG, DERRICK (2019-07-01). Redox regulation of cell state and fate. Redox Biology 25 : 101056-. ScholarBank@NUS Repository. https://doi.org/10.1016/j.redox.2018.11.014 | Abstract: | The failure in effective cancer treatment is thought to be attributed to a subpopulation of tumor cells with stem cell-like properties. These cancer stem cells (CSCs) are intimately linked to tumor initiation, heterogeneity, maintenance, recurrence and metastasis. Increasing evidence supports the view that a tight redox regulation is crucial for CSC proliferation, tumorigenicity, therapy resistance and metastasis in many cancer types. Since the distinct metabolic and epigenetic states of CSCs may influence ROS levels, and hence their malignancy, ROS modulating agents hold promise in their utility as anti-CSC agents that may improve the durability of current cancer treatments. This review will focus on (i) how ROS levels are regulated for CSCs to elicit their hallmark features; (ii) the link between ROS and metabolic plasticity of CSCs; and (iii) how ROS may interface with epigenetics that would enable CSCs to thrive in a stressful tumor microenvironment and survive therapeutic insults. | Source Title: | Redox Biology | URI: | https://scholarbank.nus.edu.sg/handle/10635/191361 | ISSN: | 2213-2317 | DOI: | 10.1016/j.redox.2018.11.014 |
Appears in Collections: | Staff Publications Elements |
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Redox regulation of cell state and fate.pdf | Accepted version | 3.11 MB | Adobe PDF | OPEN | Published | View/Download |
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