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Title: Activation of Pyroptosis by Membrane‐Anchoring AIE Photosensitizer Design: New Prospect for Photodynamic Cancer Cell Ablation
Authors: Wu, Min
Liu, Xingang 
Chen, Huan 
Duan, Yukun 
Liu, Jingjing 
Pan, Yutong 
Liu, Bin 
Keywords: Science & Technology
Physical Sciences
Chemistry, Multidisciplinary
aggregation-induced emission
membrane anchoring
photodynamic therapy
Issue Date: 2021
Publisher: Wiley
Citation: Wu, Min, Liu, Xingang, Chen, Huan, Duan, Yukun, Liu, Jingjing, Pan, Yutong, Liu, Bin (2021). Activation of Pyroptosis by Membrane‐Anchoring AIE Photosensitizer Design: New Prospect for Photodynamic Cancer Cell Ablation. Angewandte Chemie 133 (16) : 9175-9180. ScholarBank@NUS Repository.
Abstract: Pyroptosis as a lytic and inflammatory form of cell death is a powerful tool to fight against cancer. However, pyroptosis is usually activated by chemotherapeutic drugs, which limits its anti-tumor applications due to drug resistance and severe side effects. Herein, we demonstrate that membrane targeting photosensitizers can induce pyroptosis for cancer cell ablation with noninvasiveness and low side effects. A series of membrane anchoring photosensitizers (TBD-R PSs) with aggregation-induced emission (AIE) characteristics were prepared through conjugation of TBD and phenyl ring with cationic chains. Upon light irradiation, cytotoxic ROS were produced in situ, resulting in direct membrane damage and superior cancer cell ablation. Detailed study revealed that pyroptosis gradually became the dominant cell death pathway along with the increase of TBD-R PSs membrane anchoring capability. This study offers a photo-activated pyroptosis-based intervention strategy for cancer cell ablation.
Source Title: Angewandte Chemie
ISSN: 00448249
DOI: 10.1002/ange.202016399
Appears in Collections:Staff Publications

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