Please use this identifier to cite or link to this item: https://doi.org/10.1002/adfm.202001338
Title: Bacterium-Templated Polymer for Self-Selective Ablation of Multidrug-Resistant Bacteria
Authors: Qi, Guobin
Hu, Fang
Kenry 
Chong, Kok Chan 
Wu, Min
Gan, Yunn Hwen 
Liu, Bin 
Keywords: Science & Technology
Physical Sciences
Technology
Chemistry, Multidisciplinary
Chemistry, Physical
Nanoscience & Nanotechnology
Materials Science, Multidisciplinary
Physics, Applied
Physics, Condensed Matter
Chemistry
Science & Technology - Other Topics
Materials Science
Physics
aggregation-induced emission (AIE)
antimicrobial agent
bacterium-templated polymer
fluorescence imaging
photodynamic therapy
COPPER HOMEOSTASIS
Issue Date: 2020
Publisher: WILEY-V C H VERLAG GMBH
Citation: Qi, Guobin, Hu, Fang, Kenry, Chong, Kok Chan, Wu, Min, Gan, Yunn Hwen, Liu, Bin (2020). Bacterium-Templated Polymer for Self-Selective Ablation of Multidrug-Resistant Bacteria. ADVANCED FUNCTIONAL MATERIALS 30 (31). ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.202001338
Abstract: The recognition and inactivation of specific pathogenic bacteria remain an enormous scientific challenge and an important therapeutic goal. Therefore, materials that can selectively target and kill specific pathogenic bacteria, without harming beneficial strains are highly desirable. Here, a material platform is reported that exploits bacteria as a template to synthesize polymers with aggregation-induced emission (AIE) characteristic by copper-catalyzed atom transfer radical polymerization for self-selective killing of the bacteria that templates them with no antimicrobial resistance. The bacteria-templated polymers show very weak fluorescence in aqueous media, however, the fluorescence is turned on upon recognition of the bacteria used as the template to synthesize the polymer even at a low concentration of 600 ng mL . Moreover, the incorporated AIE fluorogens (AIEgens) can act as an efficient photosensitizer for reactive oxygen species (ROS) generation after bacteria surface binding, which endows the templated polymers with the capability for selective bacterial killing. The bacterium-templated synthesis is generally applicable to a wide range of bacteria, including clinically isolated multidrug-resistant bacterial strains. It is envisioned that the bacterium-templated method provides a new strategy for bacteria-specific diagnostic and therapeutic applications. −1
Source Title: ADVANCED FUNCTIONAL MATERIALS
URI: https://scholarbank.nus.edu.sg/handle/10635/188624
ISSN: 1616301X
16163028
DOI: 10.1002/adfm.202001338
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