Please use this identifier to cite or link to this item:
https://doi.org/10.1039/d0mh01582b
| Title: | Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy | Authors: | Liu, Xingang Wu, Min Wang, Meng Duan, Yukun Phan, ChiUyen Qi, Guobin Tang, Guping Liu, Bin |
Issue Date: | 2020 | Publisher: | Royal Society of Chemistry (RSC) | Citation: | Liu, Xingang, Wu, Min, Wang, Meng, Duan, Yukun, Phan, ChiUyen, Qi, Guobin, Tang, Guping, Liu, Bin (2020/12/16). Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy. Materials Horizons. ScholarBank@NUS Repository. https://doi.org/10.1039/d0mh01582b | Abstract: | A living therapeutic system based on attenuated Salmonella was developed via metabolic engineering using an aggregation-induced emission (AIE) photosensitizer MA. The engineered bacteria could localize in the tumor tissues and continue to colonize and express exogenous genes. Under light irradiation, the encoded VEGFR2 gene was released and expressed in tumor tissues, which can suppress angiogenesis induced by a T cell-mediated autoimmune response and inhibit tumor growth. | Source Title: | Materials Horizons | URI: | https://scholarbank.nus.edu.sg/handle/10635/188585 | ISSN: | 20516347 20516355 |
DOI: | 10.1039/d0mh01582b |
| Appears in Collections: | Staff Publications Elements |
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| File | Description | Size | Format | Access Settings | Version | |
|---|---|---|---|---|---|---|
| Metabolically Engineered Bacteria as Light.pdf | Submitted version | 1.44 MB | Adobe PDF | OPEN | Pre-print | View/Download |
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