Please use this identifier to cite or link to this item: https://doi.org/10.1039/d0mh01582b
Title: Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy
Authors: Liu, Xingang 
Wu, Min
Wang, Meng
Duan, Yukun 
Phan, ChiUyen
Qi, Guobin
Tang, Guping 
Liu, Bin 
Issue Date: 2020
Publisher: Royal Society of Chemistry (RSC)
Citation: Liu, Xingang, Wu, Min, Wang, Meng, Duan, Yukun, Phan, ChiUyen, Qi, Guobin, Tang, Guping, Liu, Bin (2020/12/16). Metabolically engineered bacteria as light-controlled living therapeutics for anti-angiogenesis tumor therapy. Materials Horizons. ScholarBank@NUS Repository. https://doi.org/10.1039/d0mh01582b
Abstract: A living therapeutic system based on attenuated Salmonella was developed via metabolic engineering using an aggregation-induced emission (AIE) photosensitizer MA. The engineered bacteria could localize in the tumor tissues and continue to colonize and express exogenous genes. Under light irradiation, the encoded VEGFR2 gene was released and expressed in tumor tissues, which can suppress angiogenesis induced by a T cell-mediated autoimmune response and inhibit tumor growth.
Source Title: Materials Horizons
URI: https://scholarbank.nus.edu.sg/handle/10635/188585
ISSN: 20516347
20516355
DOI: 10.1039/d0mh01582b
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