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Title: Cardiometabolic Profile of Different Body Composition Phenotypes in Children
Authors: Yi Ying Ong
Jonathan Y Huang
Navin Michael
Suresh Anand Sadananthan 
Wen Lun Yuan 
Ling-Wei Chen 
Neerja Karnani 
S Sendhil Velan 
Marielle V Fortier 
Kok Hian Tan 
Peter D Gluckman 
Fabian Yap 
Yap-Seng Chong 
Keith M Godfrey
Mary F-F Chong 
Shiao-Yng Chan 
Yung Seng Lee 
Mya-Thway Tint 
Johan G Eriksson 
Keywords: Body composition
Metabolic syndrome
Issue Date: Feb-2021
Citation: Yi Ying Ong, Jonathan Y Huang, Navin Michael, Suresh Anand Sadananthan, Wen Lun Yuan, Ling-Wei Chen, Neerja Karnani, S Sendhil Velan, Marielle V Fortier, Kok Hian Tan, Peter D Gluckman, Fabian Yap, Yap-Seng Chong, Keith M Godfrey, Mary F-F Chong, Shiao-Yng Chan, Yung Seng Lee, Mya-Thway Tint, Johan G Eriksson (2021-02). Cardiometabolic Profile of Different Body Composition Phenotypes in Children. Journal of Clinical Endocrinology and Metabolism. ScholarBank@NUS Repository.
Abstract: Context: Cardiometabolic profiles of different body composition phenotypes are poorly characterized in young children, where it is well-established that high adiposity is unfavorable, but the role of lean mass is unclear. Objective: We hypothesized that higher lean mass attenuates cardiometabolic risk in children with high fat mass. Design, setting, participants: In 6-year-old children (n=377) from the Growing Up in Singapore Towards healthy Outcomes (GUSTO) prospective birth cohort, whole-body composition was measured by quantitative magnetic resonance, a novel validated technology. Based on fat mass index (FMI) and lean mass index (LMI), 4 body composition phenotypes were derived: low FMI-low LMI (LF-LL), low FMI-high LMI (LF-HL), high FMI-low LMI (HF-LL), high FMI-high LMI (HF-HL). Main outcome measures: BMI z-score, fasting plasma glucose, insulin resistance, metabolic syndrome risk score, fatty liver index, and blood pressure. Results: Compared to the LF-HL group, children in both high FMI groups had increased BMI z-score (HF-HL: 1.43units 95% CI [1.11,1.76]; HF-LL: 0.61units [0.25,0.96]) and metabolic syndrome risk score (HF-HL: 1.64 [0.77,2.50]; HF-LL: 1.28 [0.34,2.21]). The HF-HL group also had increased fatty liver index (1.15 [0.54,1.77]). Girls in HF-HL group had lower fasting plasma glucose (-0.29mmol/L [-0.55,-0.04]) and diastolic blood pressure (-3.22mmHg [-6.03,-0.41]) than girls in the HF-LL group. No similar associations were observed in boys. Conclusions: In a multi-ethnic Asian cohort, lean mass seemed to protect against some cardiometabolic risk markers linked with adiposity, but only in girls. Fat mass index seemed more important than lean mass index in relation to cardiometabolic profiles of young children.
Source Title: Journal of Clinical Endocrinology and Metabolism
ISSN: 0021972X
DOI: 10.1210/clinem/dgab003
Appears in Collections:Staff Publications

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