Please use this identifier to cite or link to this item:
|Title:||Association between perinatal methylation of the neuronal differentiation regulator HES1 and later childhood neurocognitive function and behaviour||Authors:||Lillycrop K.A.
The Epigen Global Research Consortium
|Issue Date:||2015||Publisher:||Oxford University Press||Citation:||Lillycrop K.A., Costello P.M., Teh A.L., Murray R.J., Clarke-Harris R., Barton S.J., Garratt E.S., Ngo S., Sheppard A.M., Wong J., Dogra S., Burdge G.C., Cooper C., Inskip H.M., Gale C.R., Gluckman P.D., Harvey N.C., Chong Y.-S., Yap F., Meaney M.J., Rifkin-Graboi A., Holbrook J.D., Godfrey K.M., The Epigen Global Research Consortium (2015). Association between perinatal methylation of the neuronal differentiation regulator HES1 and later childhood neurocognitive function and behaviour. International Journal of Epidemiology 44 (4) : 1263 - 1276. ScholarBank@NUS Repository. https://doi.org/10.1093/ije/dyv052||Abstract:||Background: Early life environments induce long-term changes in neurocognitive development and behaviour. In animal models, early environmental cues affect neuropsychological phenotypes via epigenetic processes but, as yet, there is little direct evidence for such mechanisms in humans. Method: We examined the relation between DNA methylation at birth and child neuropsychological outcomes in two culturally diverse populations using a genome-wide methylation analysis and validation by pyrosequencing. Results: Within the UK Southampton Women's Survey (SWS) we first identified 41 differentially methylated regions of interest (DMROI) at birth associated with child's full-scale IQ at age 4 years. Associations between HES1 DMROI methylation and later cognitive function were confirmed by pyrosequencing in 175 SWS children. Consistent with these findings, higher HES1 methylation was associated with higher executive memory function in a second independent group of 200 SWS 7-year-olds. Finally, we examined a pathway for this relationship within a Singaporean cohort (n=108). Here, HES1 DMROI methylation predicted differences in early infant behaviour, known to be associated with academic success. In vitro, methylation of HES1 inhibited ETS transcription factor binding, suggesting a functional role of this site. Conclusions: Thus, our findings suggest that perinatal epigenetic processes mark later neurocognitive function and behaviour, providing support for a role of epigenetic processes in mediating the long-term consequences of early life environment on cognitive development. © The Author 2015.||Source Title:||International Journal of Epidemiology||URI:||https://scholarbank.nus.edu.sg/handle/10635/185890||ISSN:||03005771||DOI:||10.1093/ije/dyv052|
|Appears in Collections:||Elements|
Show full item record
Files in This Item:
|(43).pdf||630.3 kB||Adobe PDF|
checked on Jul 25, 2021
checked on Jul 29, 2021
checked on Jul 29, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.