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Title: Influence of metabolic-linked early life factors on the eruption timing of the first primary tooth
Authors: Un Lam C. 
Hsu C.-Y.S. 
Yee R. 
Koh D. 
Lee Y.S. 
Chong M.F.-F. 
Cai M. 
Kwek K. 
Saw S.M. 
Godfrey K.
Gluckman P. 
Chong Y.S. 
Keywords: Birth
Metabolic links
Primary dentition
Tooth eruption
Issue Date: 2016
Publisher: Springer Verlag
Citation: Un Lam C., Hsu C.-Y.S., Yee R., Koh D., Lee Y.S., Chong M.F.-F., Cai M., Kwek K., Saw S.M., Godfrey K., Gluckman P., Chong Y.S. (2016). Influence of metabolic-linked early life factors on the eruption timing of the first primary tooth. Clinical Oral Investigations 20 (8) : 1871 - 1879. ScholarBank@NUS Repository.
Abstract: Aim: Early eruption of permanent teeth has been associated with childhood obesity and diabetes mellitus, suggesting links between tooth eruption and metabolic conditions. This longitudinal study aimed to identify pre-, peri- and postnatal factors with metabolic consequences during infancy that may affect the eruption timing of the first primary tooth (ETFT) in children from an ethnically heterogeneous population residing within the same community. Material and methods: Participants were recruited (n = 1033) through the GUSTO (Growing Up in Singapore Towards healthy Outcomes) birth cohort (n = 1237). Oral examinations were performed at 3-month intervals from 6 to 18 months of age. Crude and adjusted analyses, with generalized linear modelling, were conducted to link ETFT to potential determinants occurring during pregnancy, delivery/birth and early infancy. Results: Overall mean eruption age of the first primary tooth was 8.5 (SD 2.6) months. Earlier tooth eruption was significantly associated with infant’s rate of weight gain during the first 3 months of life and increased maternal childbearing age. Compared to their Chinese counterparts, Malay and Indian children experienced significantly delayed tooth eruption by 1.2 and 1.7 months, respectively. Conclusions: Infant weight gain from birth to 3 months, ethnicity and maternal childbearing age were significant determinants of first tooth eruption timing. Early life influences can affect primary tooth development, possibly via metabolic pathways. Clinical relevance: Timing of tooth eruption is linked to general growth and metabolic function. Therefore, it has potential in forecasting oral and systemic conditions such as caries and obesity. © 2015, Springer-Verlag Berlin Heidelberg.
Source Title: Clinical Oral Investigations
ISSN: 14326981
Appears in Collections:Staff Publications

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