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https://doi.org/10.1111/nph.16947
Title: | Genetics of autoimmunity in plants: an evolutionary genetics perspective | Authors: | Wan, Wei-Lin Kim, Sang-Tae Castel, Baptiste Charoennit, Nuri Chae, Eunyoung |
Keywords: | Science & Technology Life Sciences & Biomedicine Plant Sciences autoimmunity cell death epistasis genetic incompatibility guardee hybrid necrosis NLR plant immunity DISEASE-RESISTANCE GENES HYBRID NECROSIS SALICYLIC-ACID DOWNY MILDEW PHYTOPHTHORA-INFESTANS SIGNAL-TRANSDUCTION PATHOGEN EFFECTORS NATURAL VARIATION IMMUNE RECEPTORS TETRAPLOID WHEAT |
Issue Date: | 25-Oct-2020 | Publisher: | WILEY | Citation: | Wan, Wei-Lin, Kim, Sang-Tae, Castel, Baptiste, Charoennit, Nuri, Chae, Eunyoung (2020-10-25). Genetics of autoimmunity in plants: an evolutionary genetics perspective. NEW PHYTOLOGIST. ScholarBank@NUS Repository. https://doi.org/10.1111/nph.16947 | Abstract: | © 2020 The Authors. New Phytologist © 2020 New Phytologist Foundation Autoimmunity in plants has been found in numerous hybrids as a form of hybrid necrosis and mutant panels. Uncontrolled cell death is a main cellular outcome of autoimmunity, which negatively impacts growth. Its occurrence highlights the vulnerable nature of the plant immune system. Genetic investigation of autoimmunity in hybrid plants revealed that extreme variation in the immune receptor repertoire is a major contributor, reflecting an evolutionary conundrum that plants face in nature. In this review, we discuss natural variation in the plant immune system and its contribution to fitness. The value of autoimmunity genetics lies in its ability to identify combinations of a natural immune receptor and its partner that are predisposed to triggering autoimmunity. The network of immune components for autoimmunity becomes instrumental in revealing mechanistic details of how immune receptors recognize cellular invasion and activate signaling. The list of autoimmunity-risk variants also allows us to infer evolutionary processes contributing to their maintenance in the natural population. Our approach to autoimmunity, which integrates mechanistic understanding and evolutionary genetics, has the potential to serve as a prognosis tool to optimize immunity in crops. | Source Title: | NEW PHYTOLOGIST | URI: | https://scholarbank.nus.edu.sg/handle/10635/185200 | ISSN: | 0028646X 14698137 |
DOI: | 10.1111/nph.16947 |
Appears in Collections: | Staff Publications Elements |
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New Phytologist Tansley Review Wan et al.pdf | 2.93 MB | Adobe PDF | OPEN | Post-print | View/Download |
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