Please use this identifier to cite or link to this item: https://doi.org/10.3174/ajnr.A1852
Title: Perfusion CT in squamous cell carcinoma of the upper aerodigestive tract: Long-term predictive value of baseline perfusion CT measurements
Authors: Bisdas, S
Rumboldt, Z
Šurlan-Popovi?, K
Baghi, M
Koh, T.S 
Vogl, T.J
Mack, M.G
Keywords: cisplatin
adult
aged
article
cancer chemotherapy
cancer control
cancer radiotherapy
cancer recurrence
cancer surgery
cancer survival
computer assisted tomography
digestive system
endoscopy
female
follow up
human
hypopharynx
long term care
lymph node
major clinical study
male
mucosa inflammation
nephrotoxicity
nuclear magnetic resonance imaging
oropharynx
overall survival
perfusion
prediction
radiation dose
respiratory system
squamous cell carcinoma
upper aerodigestive tract
Adult
Aged
Aged, 80 and over
Antineoplastic Agents
Carcinoma, Squamous Cell
Combined Modality Therapy
Female
Follow-Up Studies
Humans
Kaplan-Meiers Estimate
Male
Middle Aged
Neoplasm Recurrence, Local
Oropharyngeal Neoplasms
Predictive Value of Tests
Prospective Studies
Radiotherapy
ROC Curve
Sensitivity and Specificity
Tomography, X-Ray Computed
Issue Date: 2010
Publisher: American Society of Neuroradiology
Citation: Bisdas, S, Rumboldt, Z, Šurlan-Popovi?, K, Baghi, M, Koh, T.S, Vogl, T.J, Mack, M.G (2010). Perfusion CT in squamous cell carcinoma of the upper aerodigestive tract: Long-term predictive value of baseline perfusion CT measurements. American Journal of Neuroradiology 31 (3) : 576-581. ScholarBank@NUS Repository. https://doi.org/10.3174/ajnr.A1852
Rights: Attribution 4.0 International
Abstract: BACKGROUND AND PURPOSE: PCT studies hold short-term predictive value in patients treated with chemoradiotherapy. Our aim was to examine the long-term predictive value of baseline PCT studies for local tumor control and overall survival in SCCA of the upper aerodigestive tract treated with chemoradiotherapy. MATERIALS AND METHODS: Eighty-four patients with advanced SCCA underwent PCT followed by concomitant chemoradiation. The acquired perfusion maps represented BF, BV, MTT, and PS. Visual analysis of the parametric maps for identification of tumor perfusion patterns was conducted. ROC curves, t tests, and Kaplan-Meier survival curves were plotted for local disease control and overall survival. RESULTS: The median time of local tumor control was 24 months. The BF and PS values were significantly higher in patients who had no recurrence than in those with local failure (P ? .02). The BF and PS were predictive (P ? .0006) but BV and MTT held no significant predictive values for local tumor control. The patients with high BF and PS had a longer local tumor control than the patients with hypoperfused tumors (P = .0007). A visually detected BF-BV mismatch had a sensitivity/specificity of 63%/66% (P = .03) and 59%/69% (P = .03) for local tumor control and OS, respectively. Patients without mismatch lived significantly longer than patients with mismatch (P = .01). CONCLUSIONS: BF, PS, and mismatch of BF-BV are significant predictors of local tumor control after chemoradiation in SCCA of the upper aerodigestive tract.
Source Title: American Journal of Neuroradiology
URI: https://scholarbank.nus.edu.sg/handle/10635/183917
ISSN: 0195-6108
DOI: 10.3174/ajnr.A1852
Rights: Attribution 4.0 International
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