Please use this identifier to cite or link to this item: https://doi.org/10.1155/2016/2947136
Title: Multilevel Deficiency of White Matter Connectivity Networks in Alzheimer's Disease: A Diffusion MRI Study with DTI and HARDI Models
Authors: Wang, T
Shi, F
Jin, Y
Yap, P.-T
Wee, C.-Y 
Zhang, J
Yang, C
Li, X
Xiao, S
Shen, D
Keywords: aged
Alzheimer disease
Article
clinical article
connectome
controlled study
corpus callosum
diffusion tensor imaging
diffusion weighted imaging
female
high angular resolution diffusion imaging
hippocampus
human
male
model
neuroimaging
precuneus
pyramidal tract
temporal lobe
thalamus
white matter
Alzheimer disease
diffusion tensor imaging
metabolism
middle aged
nerve cell network
pathology
very elderly
white matter
Aged
Aged, 80 and over
Alzheimer Disease
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Female
Humans
Male
Middle Aged
Nerve Net
White Matter
Issue Date: 2016
Citation: Wang, T, Shi, F, Jin, Y, Yap, P.-T, Wee, C.-Y, Zhang, J, Yang, C, Li, X, Xiao, S, Shen, D (2016). Multilevel Deficiency of White Matter Connectivity Networks in Alzheimer's Disease: A Diffusion MRI Study with DTI and HARDI Models. Neural Plasticity 2016 : 2947136. ScholarBank@NUS Repository. https://doi.org/10.1155/2016/2947136
Rights: Attribution 4.0 International
Abstract: Alzheimer's disease (AD) is the most common form of dementia in elderly people. It is an irreversible and progressive brain disease. In this paper, we utilized diffusion-weighted imaging (DWI) to detect abnormal topological organization of white matter (WM) structural networks. We compared the differences between WM connectivity characteristics at global, regional, and local levels in 26 patients with probable AD and 16 normal control (NC) elderly subjects, using connectivity networks constructed with the diffusion tensor imaging (DTI) model and the high angular resolution diffusion imaging (HARDI) model, respectively. At the global level, we found that the WM structural networks of both AD and NC groups had a small-world topology; however, the AD group showed a significant decrease in both global and local efficiency, but an increase in clustering coefficient and the average shortest path length. We further found that the AD patients had significantly decreased nodal efficiency at the regional level, as well as weaker connections in multiple local cortical and subcortical regions, such as precuneus, temporal lobe, hippocampus, and thalamus. The HARDI model was found to be more advantageous than the DTI model, as it was more sensitive to the deficiencies in AD at all of the three levels. @ 2016 Tao Wang et al.
Source Title: Neural Plasticity
URI: https://scholarbank.nus.edu.sg/handle/10635/183724
ISSN: 20905904
DOI: 10.1155/2016/2947136
Rights: Attribution 4.0 International
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