Please use this identifier to cite or link to this item: https://doi.org/10.1155/2014/506479
Title: Extended Renal Outcomes with Use of Iodixanol versus Iohexol after Coronary Angiography
Authors: Chua, H.-R 
Horrigan, M
McIntosh, E
Bellomo, R
Keywords: creatinine
iodixanol
iohexol
contrast medium
iodixanol
iodobenzoic acid derivative
iohexol
acute kidney failure
adult
age
aged
angiocardiography
Article
comparative study
contrast enhancement
contrast induced nephropathy
creatinine blood level
critical illness
female
gender
glomerulus filtration rate
heart failure
high risk patient
human
intraaortic balloon pump
kidney dysfunction
major clinical study
male
retrospective study
ST segment elevation myocardial infarction
Acute Kidney Injury
age distribution
angiocardiography
Australia
cohort analysis
incidence
prognosis
Renal Insufficiency, Chronic
risk assessment
sex ratio
statistics and numerical data
time
Acute Kidney Injury
Age Distribution
Aged
Cohort Studies
Contrast Media
Coronary Angiography
Female
Humans
Incidence
Iohexol
Male
Prognosis
Renal Insufficiency, Chronic
Risk Assessment
Sex Distribution
Time Factors
Triiodobenzoic Acids
Victoria
Issue Date: 2014
Citation: Chua, H.-R, Horrigan, M, McIntosh, E, Bellomo, R (2014). Extended Renal Outcomes with Use of Iodixanol versus Iohexol after Coronary Angiography. BioMed Research International 2014 : 506479. ScholarBank@NUS Repository. https://doi.org/10.1155/2014/506479
Rights: Attribution 4.0 International
Abstract: The impact of isoosmolar versus low-osmolar contrast media (CM) administration on contrast-induced acute kidney injury (CI-AKI) and extended renal dysfunction (ERD) is unclear. We retrospectively examined incidences of CI-AKI and ERD in patients who received iodixanol (isoosmolar) versus iohexol (low-osmolar) during angiography for cardiac indications. Of 713 patients, 560 (cohort A), 190 (cohort B), and 172 (cohort C) had serum creatinine monitored at 3 days, 30 days, and 6 months after angiography, respectively. 18% of cohort A developed CI-AKI, which was more common with iodixanol than iohexol (22% versus 13%, P = 0.006). However, patients given iodixanol were older with lower baseline estimated glomerular filtration rates (eGFR). On multivariate analysis, independent associations with higher CI-AKI risk include age >65 years, female gender, cardiac failure, ST-elevation myocardial infarction, intra-aortic balloon pump, and critical illness, but not CM type, higher CM load, or eGFR < 45 mL/min/1.73 m2. 32% of cohort B and 34% of cohort C had ERD at 30 days and 6 months, while 44% and 41% of subcohorts had ERD at 90 days and 1 year, respectively. CI-AKI, but not CM type, was associated with medium- and longer-term ERD, with 3-fold higher risk. Advanced age, emergent cardiac conditions, and critical illness are stronger predictors of CI-AKI, compared with CM-related factors. CI-AKI predicts longer-term ERD. © 2014 Horng-Ruey Chua et al.
Source Title: BioMed Research International
URI: https://scholarbank.nus.edu.sg/handle/10635/183693
ISSN: 23146133
DOI: 10.1155/2014/506479
Rights: Attribution 4.0 International
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1155_2014_506479.pdf1.33 MBAdobe PDF

OPEN

NoneView/Download

SCOPUSTM   
Citations

7
checked on May 20, 2022

Page view(s)

121
checked on May 12, 2022

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons