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https://doi.org/10.1155/2017/7351238
Title: | Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats | Authors: | Zhang, Y.-T Jin, H Wang, J.-H Wen, L.-Y Yang, Y Ruan, J.-W Zhang, S.-X Ling, E.-A Ding, Y Zeng, Y.-S |
Keywords: | beta tubulin choline acetyltransferase neurotrophin 3 neurotrophin 3 adult animal experiment animal model Article cell nucleus controlled study cytoplasm electroacupuncture electrode electrostimulation female hindlimb muscle immunofluorescence muscle atrophy neuroprotection nonhuman oligodendroglia protein expression rat spinal cord motoneuron spinal cord transsection spinal cord ventral horn animal anterior horn cell electroacupuncture electrostimulation innervation metabolism motoneuron muscle atrophy pathology pathophysiology physiology skeletal muscle spinal cord spinal cord injury Sprague Dawley rat tail Animals Anterior Horn Cells Electric Stimulation Electroacupuncture Female Motor Neurons Muscle, Skeletal Muscular Atrophy Neurotrophin 3 Rats, Sprague-Dawley Spinal Cord Spinal Cord Injuries Tail |
Issue Date: | 2017 | Publisher: | Hindawi | Citation: | Zhang, Y.-T, Jin, H, Wang, J.-H, Wen, L.-Y, Yang, Y, Ruan, J.-W, Zhang, S.-X, Ling, E.-A, Ding, Y, Zeng, Y.-S (2017). Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats. Neural Plasticity 2017 : 7351238. ScholarBank@NUS Repository. https://doi.org/10.1155/2017/7351238 | Rights: | Attribution 4.0 International | Abstract: | Spinal cord injury (SCI) often results in death of spinal neurons and atrophy of muscles which they govern. Thus, following SCI, reorganizing the lumbar spinal sensorimotor pathways is crucial to alleviate muscle atrophy. Tail nerve electrical stimulation (TANES) has been shown to activate the central pattern generator (CPG) and improve the locomotion recovery of spinal contused rats. Electroacupuncture (EA) is a traditional Chinese medical practice which has been proven to have a neural protective effect. Here, we examined the effects of TANES and EA on lumbar motor neurons and hindlimb muscle in spinal transected rats, respectively. From the third day postsurgery, rats in the TANES group were treated 5 times a week and those in the EA group were treated once every other day. Four weeks later, both TANES and EA showed a significant impact in promoting survival of lumbar motor neurons and expression of choline acetyltransferase (ChAT) and ameliorating atrophy of hindlimb muscle after SCI. Meanwhile, the expression of neurotrophin-3 (NT-3) in the same spinal cord segment was significantly increased. These findings suggest that TANES and EA can augment the expression of NT-3 in the lumbar spinal cord that appears to protect the motor neurons as well as alleviate muscle atrophy. © 2017 Yu-Ting Zhang et al. | Source Title: | Neural Plasticity | URI: | https://scholarbank.nus.edu.sg/handle/10635/183563 | ISSN: | 2090-5904 | DOI: | 10.1155/2017/7351238 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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