Please use this identifier to cite or link to this item: https://doi.org/10.1155/2017/7351238
Title: Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats
Authors: Zhang, Y.-T
Jin, H
Wang, J.-H
Wen, L.-Y
Yang, Y
Ruan, J.-W
Zhang, S.-X
Ling, E.-A 
Ding, Y
Zeng, Y.-S
Keywords: beta tubulin
choline acetyltransferase
neurotrophin 3
neurotrophin 3
adult
animal experiment
animal model
Article
cell nucleus
controlled study
cytoplasm
electroacupuncture
electrode
electrostimulation
female
hindlimb muscle
immunofluorescence
muscle atrophy
neuroprotection
nonhuman
oligodendroglia
protein expression
rat
spinal cord motoneuron
spinal cord transsection
spinal cord ventral horn
animal
anterior horn cell
electroacupuncture
electrostimulation
innervation
metabolism
motoneuron
muscle atrophy
pathology
pathophysiology
physiology
skeletal muscle
spinal cord
spinal cord injury
Sprague Dawley rat
tail
Animals
Anterior Horn Cells
Electric Stimulation
Electroacupuncture
Female
Motor Neurons
Muscle, Skeletal
Muscular Atrophy
Neurotrophin 3
Rats, Sprague-Dawley
Spinal Cord
Spinal Cord Injuries
Tail
Issue Date: 2017
Publisher: Hindawi
Citation: Zhang, Y.-T, Jin, H, Wang, J.-H, Wen, L.-Y, Yang, Y, Ruan, J.-W, Zhang, S.-X, Ling, E.-A, Ding, Y, Zeng, Y.-S (2017). Tail Nerve Electrical Stimulation and Electro-Acupuncture Can Protect Spinal Motor Neurons and Alleviate Muscle Atrophy after Spinal Cord Transection in Rats. Neural Plasticity 2017 : 7351238. ScholarBank@NUS Repository. https://doi.org/10.1155/2017/7351238
Rights: Attribution 4.0 International
Abstract: Spinal cord injury (SCI) often results in death of spinal neurons and atrophy of muscles which they govern. Thus, following SCI, reorganizing the lumbar spinal sensorimotor pathways is crucial to alleviate muscle atrophy. Tail nerve electrical stimulation (TANES) has been shown to activate the central pattern generator (CPG) and improve the locomotion recovery of spinal contused rats. Electroacupuncture (EA) is a traditional Chinese medical practice which has been proven to have a neural protective effect. Here, we examined the effects of TANES and EA on lumbar motor neurons and hindlimb muscle in spinal transected rats, respectively. From the third day postsurgery, rats in the TANES group were treated 5 times a week and those in the EA group were treated once every other day. Four weeks later, both TANES and EA showed a significant impact in promoting survival of lumbar motor neurons and expression of choline acetyltransferase (ChAT) and ameliorating atrophy of hindlimb muscle after SCI. Meanwhile, the expression of neurotrophin-3 (NT-3) in the same spinal cord segment was significantly increased. These findings suggest that TANES and EA can augment the expression of NT-3 in the lumbar spinal cord that appears to protect the motor neurons as well as alleviate muscle atrophy. © 2017 Yu-Ting Zhang et al.
Source Title: Neural Plasticity
URI: https://scholarbank.nus.edu.sg/handle/10635/183563
ISSN: 2090-5904
DOI: 10.1155/2017/7351238
Rights: Attribution 4.0 International
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