Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms18122589
Title: The role of resveratrol in cancer therapy
Authors: Ko, J.-H
Sethi, G 
Um, J.-Y
Shanmugam, M.K 
Arfuso, F
Kumar, A.P 
Bishayee, A
Ahn, K.S
Keywords: antineoplastic agent
polyphenol
pterostilbene
reactive oxygen metabolite
resveratrol
antineoplastic agent
resveratrol
stilbene derivative
antiinflammatory activity
antimicrobial activity
antineoplastic activity
antioxidant activity
cancer cell
cancer growth
cancer inhibition
cancer survival
cancer therapy
carcinogenesis
chemoprophylaxis
cognitive defect
drug bioavailability
early cancer diagnosis
heart protection
human
immunosuppressive treatment
malignant neoplasm
molecularly targeted therapy
multidrug resistance
nonhuman
phase 1 clinical trial (topic)
phase 2 clinical trial (topic)
protein expression
randomized controlled trial (topic)
Review
signal transduction
animal
drug effect
drug potentiation
drug resistance
gene expression regulation
gene regulatory network
genetics
neoplasm
Animals
Antineoplastic Agents, Phytogenic
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Drug Synergism
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Humans
Neoplasms
Stilbenes
Issue Date: 2017
Publisher: MDPI
Citation: Ko, J.-H, Sethi, G, Um, J.-Y, Shanmugam, M.K, Arfuso, F, Kumar, A.P, Bishayee, A, Ahn, K.S (2017). The role of resveratrol in cancer therapy. International Journal of Molecular Sciences 18 (12) : 2589. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms18122589
Rights: Attribution 4.0 International
Abstract: Natural product compounds have recently attracted significant attention from the scientific community for their potent effects against inflammation-driven diseases, including cancer. A significant amount of research, including preclinical, clinical, and epidemiological studies, has indicated that dietary consumption of polyphenols, found at high levels in cereals, pulses, vegetables, and fruits, may prevent the evolution of an array of diseases, including cancer. Cancer development is a carefully orchestrated progression where normal cells acquires mutations in their genetic makeup, which cause the cells to continuously grow, colonize, and metastasize to other organs such as the liver, lungs, colon, and brain. Compounds that modulate these oncogenic processes can be considered as potential anti-cancer agents that may ultimately make it to clinical application. Resveratrol, a natural stilbene and a non-flavonoid polyphenol, is a phytoestrogen that possesses anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. It has been reported that resveratrol can reverse multidrug resistance in cancer cells, and, when used in combination with clinically used drugs, it can sensitize cancer cells to standard chemotherapeutic agents. Several novel analogs of resveratrol have been developed with improved anti-cancer activity, bioavailability, and pharmacokinetic profile. The current focus of this review is resveratrol’s in vivo and in vitro effects in a variety of cancers, and intracellular molecular targets modulated by this polyphenol. This is also accompanied by a comprehensive update of the various clinical trials that have demonstrated it to be a promising therapeutic and chemopreventive agent. © 2017 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Molecular Sciences
URI: https://scholarbank.nus.edu.sg/handle/10635/183481
ISSN: 1661-6596
DOI: 10.3390/ijms18122589
Rights: Attribution 4.0 International
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