Please use this identifier to cite or link to this item: https://doi.org/10.1186/bcr1319
Title: CYP17 gene polymorphism in relation to breast cancer risk: a case-control study
Authors: Einarsdóttir, K
Rylander-Rudqvist, T
Humphreys, K
Ahlberg, S
Jonasdottir, G
Weiderpass, E
Chia, K.S 
Ingelman-Sundberg, M
Persson, I
Liu, J 
Hall, P
Wedrén, S
Keywords: steroid 17alpha monooxygenase
aged
breast tumor
case control study
female
genetic polymorphism
genetic predisposition
genetics
human
middle aged
postmenopause
risk
Aged
Breast Neoplasms
Case-Control Studies
Female
Genetic Predisposition to Disease
Humans
Middle Aged
Odds Ratio
Polymorphism, Genetic
Postmenopause
Steroid 17-alpha-Hydroxylase
Issue Date: 2005
Citation: Einarsdóttir, K, Rylander-Rudqvist, T, Humphreys, K, Ahlberg, S, Jonasdottir, G, Weiderpass, E, Chia, K.S, Ingelman-Sundberg, M, Persson, I, Liu, J, Hall, P, Wedrén, S (2005). CYP17 gene polymorphism in relation to breast cancer risk: a case-control study. Breast cancer research : BCR 7 (6) : R890-R896. ScholarBank@NUS Repository. https://doi.org/10.1186/bcr1319
Rights: Attribution 4.0 International
Abstract: INTRODUCTION: The c.1-34T>C 5' promoter region polymorphism in cytochrome P450c17 (CYP17), a key enzyme in the biosynthesis of estrogen, has been associated with breast cancer risk, but most previous studies have been relatively small.METHODS: We genotyped 1,544 incident cases of primary breast cancer and 1,502 population controls, all postmenopausal Swedish women, for the CYP17 c.1-34T>C polymorphism and calculated odds ratios (ORs) and 95% confidence intervals (CIs) from logistic regression models.RESULTS: No overall association was found between CYP17 c.1-34T>C and breast cancer risk, OR 1.0 (95% CI 0.8-1.3) for the A2/A2 (CC) carriers compared to the A1/A1 (TT) carriers, regardless of histopathology. We detected an interaction between CYP17 c.1-34T>C and age at menarche (P = 0.026) but regarded that as a chance finding as no dose-response pattern was evident. Other breast cancer risk factors, including menopausal hormone use and diabetes mellitus, did not modify the overall results.CONCLUSION: It is unlikely that CYP17 c.1-34T>C has a role in breast cancer etiology, overall or in combination with established non-genetic breast cancer risk factors.
Source Title: Breast cancer research : BCR
URI: https://scholarbank.nus.edu.sg/handle/10635/183289
ISSN: 1465542X
DOI: 10.1186/bcr1319
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications
Elements

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1186_bcr1319.pdf212.31 kBAdobe PDF

OPEN

NoneView/Download

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons