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Title: Role of translationally controlled tumor protein in cancer progression
Authors: Chan, T.H.M 
Chen, L 
Guan, X.-Y
Keywords: Schizosaccharomycetaceae
Issue Date: 2012
Citation: Chan, T.H.M, Chen, L, Guan, X.-Y (2012). Role of translationally controlled tumor protein in cancer progression. Biochemistry Research International : 369384. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Translationally controlled tumor protein (TCTP) is a highly conserved and ubiquitously expressed protein in all eukaryoteshighlighting its important functions in the cell. Previous studies revealed that TCTP is implicated in many biological processes, including cell growth, tumor reversion, and induction of pluripotent stem cell. A recent study on the solution structure from fission yeast orthologue classifies TCTP under a family of small chaperone proteins. There is growing evidence in the literature that TCTP is a multifunctional protein and exerts its biological activity at the extracellular and intracellular levels. Although TCTP is not a tumor-specific protein, our research group, among several others, focused on the role(s) of TCTP in cancer progression. In this paper, we will summarize the current scientific knowledge of TCTP in different aspects, and the precise oncogenic mechanisms of TCTP will be discussed in detail. © Copyright 2012 Tim Hon Man Chan et al.
Source Title: Biochemistry Research International
ISSN: 20902247
DOI: 10.1155/2012/369384
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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