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https://doi.org/10.1038/srep19377
Title: | Notch1 deficiency decreases hepatic lipid accumulation by induction of fatty acid oxidation | Authors: | Song, N.-J Yun, U.J Yang, S Wu, C Seo, C.-R Gwon, A.-R Baik, S.-H Choi, Y Choi, B.Y Bahn, G Kim, S Kwon, S.-M Park, J.S Baek, S.H Park, T.J Yoon, K Kim, B.-J Mattson, M.P Lee, S.-J Jo, D.-G Park, K.W |
Keywords: | fatty acid Notch1 receptor adipocyte adverse effects animal cell line deficiency diet drug effects fatty liver gene silencing genetics human insulin resistance lipid metabolism liver metabolism mouse obesity oxidation reduction reaction oxidative stress pathology RNA interference signal transduction Adipocytes Animals Cell Line Diet Fatty Acids Fatty Liver Gene Knockdown Techniques Humans Insulin Resistance Lipid Metabolism Liver Mice Obesity Oxidation-Reduction Oxidative Stress Receptor, Notch1 RNA Interference Signal Transduction |
Issue Date: | 2016 | Publisher: | Nature Publishing Group | Citation: | Song, N.-J, Yun, U.J, Yang, S, Wu, C, Seo, C.-R, Gwon, A.-R, Baik, S.-H, Choi, Y, Choi, B.Y, Bahn, G, Kim, S, Kwon, S.-M, Park, J.S, Baek, S.H, Park, T.J, Yoon, K, Kim, B.-J, Mattson, M.P, Lee, S.-J, Jo, D.-G, Park, K.W (2016). Notch1 deficiency decreases hepatic lipid accumulation by induction of fatty acid oxidation. Scientific Reports 6 : 19377. ScholarBank@NUS Repository. https://doi.org/10.1038/srep19377 | Rights: | Attribution 4.0 International | Abstract: | Notch signaling pathways modulate various cellular processes, including cell proliferation, differentiation, adhesion, and communication. Recent studies have demonstrated that Notch1 signaling also regulates hepatic glucose production and lipid synthesis. However, the effect of Notch1 signaling on hepatic lipid oxidation has not yet been directly investigated. To define the function of Notch1 signaling in hepatic lipid metabolism, wild type mice and Notch1 deficient antisense transgenic (NAS) mice were fed a high-fat diet. High-fat diet-fed NAS mice exhibited a marked reduction in hepatic triacylglycerol accumulation compared with wild type obese mice. The improved fatty liver was associated with an increased expression of hepatic genes involved in fatty acid oxidation. However, lipogenic genes were not differentially expressed in the NAS liver, suggesting lipolytic-specific regulatory effects by Notch1 signaling. Expression of fatty acid oxidative genes and the rate of fatty acid oxidation were also increased by inhibition of Notch1 signaling in HepG2 cells. In addition, similar regulatory effects on lipid accumulation were observed in adipocytes. Taken together, these data show that inhibition of Notch1 signaling can regulate the expression of fatty acid oxidation genes and may provide therapeutic strategies in obesity-induced hepatic steatosis. | Source Title: | Scientific Reports | URI: | https://scholarbank.nus.edu.sg/handle/10635/182514 | ISSN: | 2045-2322 | DOI: | 10.1038/srep19377 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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