Dietary n-3 Fatty Acid, ?-Tocopherol, Zinc, Vitamin D, Vitamin C, and ?-carotene are Associated with Age-Related Macular Degeneration in Japan
Aoki, A Inoue, M Nguyen, E Obata, R Kadonosono, K Shinkai, S Hashimoto, H Sasaki, S Yanagi, Y
Aoki, A
Inoue, M
Nguyen, E
Obata, R
Kadonosono, K
Shinkai, S
Hashimoto, H
Sasaki, S
Citations
Altmetric:
Alternative Title
Abstract
This case-control study reports the association between nutrient intake and neovascular age-related macular degeneration (AMD) in Japan. The nutrient intake of 161 neovascular AMD cases from two university hospitals and 369 population-based control subjects from a cohort study was assessed using a brief-Type self-Administered questionnaire on diet history, which required respondent recall of the usual intake of 58 foods during the preceding month. Energy-Adjusted nutrient intake values were compared between the groups. Logistic regression analysis was used to estimate odds ratios (ORs) and 95% CIs adjusted for smoking history, age, sex, chronic disease history, supplement use, and alcohol consumption. Logistic regression analysis demonstrated that low intakes of n-3 fatty acid, ?-Tocopherol, zinc, vitamin D, vitamin C, and ?-carotene were associated with neovascular AMD (Trend P < 0.0001 for n-3 fatty acid, Trend P < 0.0001 for ?-Tocopherol, Trend P < 0.0001 for zinc, Trend P = 0.002 for vitamin D, Trend P = 0.04 for vitamin C, Trend P = 0.0004 for ?-carotene). There was no association with retinol or cryptoxanthin intake and neovascular AMD (P = 0.67, 0.06).
Keywords
alpha tocopherol, ascorbic acid, beta carotene, omega 3 fatty acid, vitamin D, zinc, aged, caloric intake, case control study, dietary supplement, female, human, Japan, macular degeneration, male, questionnaire, risk factor, statistical model, very elderly, Aged, Aged, 80 and over, alpha-Tocopherol, Ascorbic Acid, beta Carotene, Case-Control Studies, Dietary Supplements, Energy Intake, Fatty Acids, Omega-3, Female, Humans, Japan, Logistic Models, Macular Degeneration, Male, Risk Factors, Surveys and Questionnaires, Vitamin D, Zinc
Source Title
Scientific Reports
Publisher
Nature Publishing Group
Series/Report No.
Collections
Rights
Attribution 4.0 International
Date
2016
DOI
10.1038/srep20723
Type
Article