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https://doi.org/10.18632/oncotarget.7333
Title: | MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells | Authors: | Liu, C.-Y Chan, S.W Guo, F Toloczko, A Cui, L Hong, W |
Keywords: | messenger RNA myocardin related transcription factor neu differentiation factor serum response factor transcription factor transcription factor TAZ unclassified drug hemoprotein HRG-1 protein, human MKL1 protein, human serum response factor SRF protein, human TAZ protein, human transactivator protein transcription factor tumor marker Article breast cancer cancer cell cell migration cell nucleus controlled study correlation analysis human human cell protein expression protein localization protein targeting transcription regulation upregulation breast tumor cell motion cell proliferation female gene expression regulation genetics metabolism pathology signal transduction transcription initiation tumor cell culture Biomarkers, Tumor Breast Neoplasms Cell Movement Cell Proliferation Female Gene Expression Regulation, Neoplastic Hemeproteins Humans Serum Response Factor Signal Transduction Trans-Activators Transcription Factors Transcriptional Activation Tumor Cells, Cultured |
Issue Date: | 2016 | Publisher: | Impact Journals LLC | Citation: | Liu, C.-Y, Chan, S.W, Guo, F, Toloczko, A, Cui, L, Hong, W (2016). MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells. Oncotarget 7 (12) : 13706-13716. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.7333 | Rights: | Attribution 4.0 International | Abstract: | Dysregulation of Hippo pathway results in activation of transcriptional co-activators YAP/TAZ in breast cancer. Previously, we showed that overexpression of TAZ in breast cancer promotes cell migration, invasion and tumorigenesis. Here, we show that upregulation of TAZ in breast cancers could also be due to dysregulation of TAZ transcription. Heregulin ?1 (HRG1) increases TAZ mRNA level in breast cancer cells. TAZ is a direct target of MRTF/SRF transcriptional factors which are activated by HRG1. Both MRTF/SRF and TAZ are the important downstream effectors enhancing cell migration induced by HRG1. TAZ mRNA level is correlated with nuclear localization of MRTF in breast cancer cells and the mRNA level of MRTF/SRF direct target genes in breast cancers, indicating the correlation between MRTF/SRF activity and TAZ expression. Our results provide new insights into the transcriptional regulation of TAZ and dysregulation mechanism of TAZ in breast cancer, which could be a new therapeutic strategy for breast cancer. | Source Title: | Oncotarget | URI: | https://scholarbank.nus.edu.sg/handle/10635/182490 | ISSN: | 1949-2553 | DOI: | 10.18632/oncotarget.7333 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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