Please use this identifier to cite or link to this item:
https://doi.org/10.18632/oncotarget.7333
DC Field | Value | |
---|---|---|
dc.title | MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells | |
dc.contributor.author | Liu, C.-Y | |
dc.contributor.author | Chan, S.W | |
dc.contributor.author | Guo, F | |
dc.contributor.author | Toloczko, A | |
dc.contributor.author | Cui, L | |
dc.contributor.author | Hong, W | |
dc.date.accessioned | 2020-10-31T11:38:45Z | |
dc.date.available | 2020-10-31T11:38:45Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Liu, C.-Y, Chan, S.W, Guo, F, Toloczko, A, Cui, L, Hong, W (2016). MRTF/SRF dependent transcriptional regulation of TAZ in breast cancer cells. Oncotarget 7 (12) : 13706-13716. ScholarBank@NUS Repository. https://doi.org/10.18632/oncotarget.7333 | |
dc.identifier.issn | 1949-2553 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/182490 | |
dc.description.abstract | Dysregulation of Hippo pathway results in activation of transcriptional co-activators YAP/TAZ in breast cancer. Previously, we showed that overexpression of TAZ in breast cancer promotes cell migration, invasion and tumorigenesis. Here, we show that upregulation of TAZ in breast cancers could also be due to dysregulation of TAZ transcription. Heregulin ?1 (HRG1) increases TAZ mRNA level in breast cancer cells. TAZ is a direct target of MRTF/SRF transcriptional factors which are activated by HRG1. Both MRTF/SRF and TAZ are the important downstream effectors enhancing cell migration induced by HRG1. TAZ mRNA level is correlated with nuclear localization of MRTF in breast cancer cells and the mRNA level of MRTF/SRF direct target genes in breast cancers, indicating the correlation between MRTF/SRF activity and TAZ expression. Our results provide new insights into the transcriptional regulation of TAZ and dysregulation mechanism of TAZ in breast cancer, which could be a new therapeutic strategy for breast cancer. | |
dc.publisher | Impact Journals LLC | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | messenger RNA | |
dc.subject | myocardin related transcription factor | |
dc.subject | neu differentiation factor | |
dc.subject | serum response factor | |
dc.subject | transcription factor | |
dc.subject | transcription factor TAZ | |
dc.subject | unclassified drug | |
dc.subject | hemoprotein | |
dc.subject | HRG-1 protein, human | |
dc.subject | MKL1 protein, human | |
dc.subject | serum response factor | |
dc.subject | SRF protein, human | |
dc.subject | TAZ protein, human | |
dc.subject | transactivator protein | |
dc.subject | transcription factor | |
dc.subject | tumor marker | |
dc.subject | Article | |
dc.subject | breast cancer | |
dc.subject | cancer cell | |
dc.subject | cell migration | |
dc.subject | cell nucleus | |
dc.subject | controlled study | |
dc.subject | correlation analysis | |
dc.subject | human | |
dc.subject | human cell | |
dc.subject | protein expression | |
dc.subject | protein localization | |
dc.subject | protein targeting | |
dc.subject | transcription regulation | |
dc.subject | upregulation | |
dc.subject | breast tumor | |
dc.subject | cell motion | |
dc.subject | cell proliferation | |
dc.subject | female | |
dc.subject | gene expression regulation | |
dc.subject | genetics | |
dc.subject | metabolism | |
dc.subject | pathology | |
dc.subject | signal transduction | |
dc.subject | transcription initiation | |
dc.subject | tumor cell culture | |
dc.subject | Biomarkers, Tumor | |
dc.subject | Breast Neoplasms | |
dc.subject | Cell Movement | |
dc.subject | Cell Proliferation | |
dc.subject | Female | |
dc.subject | Gene Expression Regulation, Neoplastic | |
dc.subject | Hemeproteins | |
dc.subject | Humans | |
dc.subject | Serum Response Factor | |
dc.subject | Signal Transduction | |
dc.subject | Trans-Activators | |
dc.subject | Transcription Factors | |
dc.subject | Transcriptional Activation | |
dc.subject | Tumor Cells, Cultured | |
dc.type | Article | |
dc.contributor.department | DUKE-NUS MEDICAL SCHOOL | |
dc.contributor.department | INSTITUTE OF MOLECULAR & CELL BIOLOGY | |
dc.description.doi | 10.18632/oncotarget.7333 | |
dc.description.sourcetitle | Oncotarget | |
dc.description.volume | 7 | |
dc.description.issue | 12 | |
dc.description.page | 13706-13716 | |
dc.published.state | published | |
Appears in Collections: | Elements Staff Publications |
Show simple item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_18632_oncotarget_7333.pdf | 8.44 MB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License