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https://doi.org/10.1038/ncomms11425
Title: | Ultraflexible organic amplifier with biocompatible gel electrodes | Authors: | Sekitani, T Yokota, T Kuribara, K Kaltenbrunner, M Fukushima, T Inoue, Y Sekino, M Isoyama, T Abe, Y Onodera, H Someya, T |
Keywords: | biomaterial carbon nanotube hydrogel naphthalene derivative polyethylene derivative animal cell line cell survival chemistry cytology dermis devices drug effects electrocardiography electrode electronics female fibroblast Foreign-Body Reaction goat hydrogel male pericardium pharmacology physiology pliability procedures rabbit rat Animals Biocompatible Materials Cell Line Cell Survival Dermis Electrocardiography Electrodes Electronics Female Fibroblasts Foreign-Body Reaction Goats Hydrogels Male Nanotubes, Carbon Naphthalenes Pericardium Pliability Polyethylenes Rabbits Rats |
Issue Date: | 2016 | Publisher: | Nature Publishing Group | Citation: | Sekitani, T, Yokota, T, Kuribara, K, Kaltenbrunner, M, Fukushima, T, Inoue, Y, Sekino, M, Isoyama, T, Abe, Y, Onodera, H, Someya, T (2016). Ultraflexible organic amplifier with biocompatible gel electrodes. Nature Communications 7 : 11425. ScholarBank@NUS Repository. https://doi.org/10.1038/ncomms11425 | Rights: | Attribution 4.0 International | Abstract: | In vivo electronic monitoring systems are promising technology to obtain biosignals with high spatiotemporal resolution and sensitivity. Here we demonstrate the fabrication of a biocompatible highly conductive gel composite comprising multi-walled carbon nanotube-dispersed sheet with an aqueous hydrogel. This gel composite exhibits admittance of 100 mS cm-2 and maintains high admittance even in a low-frequency range. On implantation into a living hypodermal tissue for 4 weeks, it showed a small foreign-body reaction compared with widely used metal electrodes. Capitalizing on the multi-functional gel composite, we fabricated an ultrathin and mechanically flexible organic active matrix amplifier on a 1.2-?m-thick polyethylene-naphthalate film to amplify (amplification factor: ?200) weak biosignals. The composite was integrated to the amplifier to realize a direct lead epicardial electrocardiography that is easily spread over an uneven heart tissue. © 2016, Nature Publishing Group. All rights reserved. | Source Title: | Nature Communications | URI: | https://scholarbank.nus.edu.sg/handle/10635/182479 | ISSN: | 2041-1723 | DOI: | 10.1038/ncomms11425 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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