Please use this identifier to cite or link to this item: https://doi.org/10.3390/ijms19030776
Title: Emerging roles of p53 family members in glucose metabolism
Authors: Itahana, Y 
Itahana, K 
Keywords: glucose transporter 3
glucose transporter 4
mitochondrial transcription factor A
monocarboxylate transporter 1
protein p53
protein p63
sirtuin 1
glucose
protein p53
TP63 protein, human
transcription factor
tumor protein p73
tumor suppressor protein
autophagy
dephosphorylation
diabetes mellitus
electron transport
epigenetics
gluconeogenesis
glucose metabolism
glucose transport
glycolysis
human
insulin release
insulin resistance
mitochondrial respiration
nonhuman
oxidative phosphorylation
pentose phosphate cycle
protein expression
Review
transcription regulation
animal
genetics
glycolysis
metabolism
mutation
Animals
Glucose
Glycolysis
Humans
Mutation
Transcription Factors
Tumor Protein p73
Tumor Suppressor Protein p53
Tumor Suppressor Proteins
Issue Date: 2018
Citation: Itahana, Y, Itahana, K (2018). Emerging roles of p53 family members in glucose metabolism. International Journal of Molecular Sciences 19 (3) : 776. ScholarBank@NUS Repository. https://doi.org/10.3390/ijms19030776
Rights: Attribution 4.0 International
Abstract: Glucose is the key source for most organisms to provide energy, as well as the key source for metabolites to generate building blocks in cells. The deregulation of glucose homeostasis occurs in various diseases, including the enhanced aerobic glycolysis that is observed in cancers, and insulin resistance in diabetes. Although p53 is thought to suppress tumorigenesis primarily by inducing cell cycle arrest, apoptosis, and senescence in response to stress, the non-canonical functions of p53 in cellular energy homeostasis and metabolism are also emerging as critical factors for tumor suppression. Increasing evidence suggests that p53 plays a significant role in regulating glucose homeostasis. Furthermore, the p53 family members p63 and p73, as well as gain-of-function p53 mutants, are also involved in glucose metabolism. Indeed, how this protein family regulates cellular energy levels is complicated and difficult to disentangle. This review discusses the roles of the p53 family in multiple metabolic processes, such as glycolysis, gluconeogenesis, aerobic respiration, and autophagy. We also discuss how the dysregulation of the p53 family in these processes leads to diseases such as cancer and diabetes. Elucidating the complexities of the p53 family members in glucose homeostasis will improve our understanding of these diseases. © 2018 by the authors. Licensee MDPI, Basel, Switzerland.
Source Title: International Journal of Molecular Sciences
URI: https://scholarbank.nus.edu.sg/handle/10635/182088
ISSN: 16616596
DOI: 10.3390/ijms19030776
Rights: Attribution 4.0 International
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