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https://doi.org/10.1186/1742-4690-10-5
Title: | Wrapping up the bad news - HIV assembly and release | Authors: | Meng, B Lever, A.M.L |
Keywords: | ALIX protein ESCRT protein ESCRT1 protein ESCRT2 protein ESCRT3 protein Gag protein genomic RNA ubiquitin protein ligase NEDD4 unclassified drug virus protein cell composition Human immunodeficiency virus nonhuman protein assembly protein domain protein interaction protein processing review virogenesis virus assembly virus cell transformation virus release Calcium-Binding Proteins Cell Cycle Proteins Endosomal Sorting Complexes Required for Transport gag Gene Products, Human Immunodeficiency Virus HIV Infections HIV-1 Host-Pathogen Interactions Humans Protein Processing, Post-Translational Proteolysis Ubiquitin-Protein Ligases Virus Assembly Virus Release |
Issue Date: | 2013 | Citation: | Meng, B, Lever, A.M.L (2013). Wrapping up the bad news - HIV assembly and release. Retrovirology 10 (1) : 5. ScholarBank@NUS Repository. https://doi.org/10.1186/1742-4690-10-5 | Rights: | Attribution 4.0 International | Abstract: | The late Nobel Laureate Sir Peter Medawar once memorably described viruses as 'bad news wrapped in protein'. Virus assembly in HIV is a remarkably well coordinated process in which the virus achieves extracellular budding using primarily intracellular budding machinery and also the unusual phenomenon of export from the cell of an RNA. Recruitment of the ESCRT system by HIV is one of the best documented examples of the comprehensive way in which a virus hijacks a normal cellular process. This review is a summary of our current understanding of the budding process of HIV, from genomic RNA capture through budding and on to viral maturation, but centering on the proteins of the ESCRT pathway and highlighting some recent advances in our understanding of the cellular components involved and the complex interplay between the Gag protein and the genomic RNA. © 2013 Meng and Lever; licensee BioMed Central Ltd. | Source Title: | Retrovirology | URI: | https://scholarbank.nus.edu.sg/handle/10635/181830 | ISSN: | 17424690 | DOI: | 10.1186/1742-4690-10-5 | Rights: | Attribution 4.0 International |
Appears in Collections: | Staff Publications Elements |
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