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Title: Division site positioning in bacteria: One size does not fit all
Authors: Monahan, L.G
Liew, A.T 
Bottomley, A.L
Harry, E.J
Keywords: peptidoglycan
Bacillus subtilis
Caulobacter crescentus
cell division
Escherichia coli
Myxococcus xanthus
Neisseria gonorrhoeae
protein binding
protein localization
regulatory mechanism
short survey
Staphylococcus aureus
Streptococcus pneumoniae
Streptomyces coelicolor
Issue Date: 2014
Citation: Monahan, L.G, Liew, A.T, Bottomley, A.L, Harry, E.J (2014). Division site positioning in bacteria: One size does not fit all. Frontiers in Microbiology 5 (FEB) : 19. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Spatial regulation of cell division in bacteria has been a focus of research for decades. It has been well studied in two model rod-shaped organisms, Escherichia coli and Bacillus subtilis, with the general belief that division site positioning occurs as a result of the combination of two negative regulatory systems, Min and nucleoid occlusion. These systems influence division by preventing the cytokinetic Z ring from forming anywhere other than midcell. However, evidence is accumulating for the existence of additional mechanisms that are involved in controlling Z ring positioning both in these organisms and in several other bacteria. In some cases the decision of where to divide is solved by variations on a common evolutionary theme, and in others completely different proteins and mechanisms are involved. Here we review the different ways bacteria solve the problem of finding the right place to divide. It appears that a one-size-fits-all model does not apply, and that individual species have adapted a division-site positioning mechanism that best suits their lifestyle, environmental niche and mode of growth to ensure equal partitioning of DNA for survival of the next generation. © 2014 Monahan, Liew, Bottomley and Harry.
Source Title: Frontiers in Microbiology
ISSN: 1664302X
DOI: 10.3389/fmicb.2014.00019
Rights: Attribution 4.0 International
Appears in Collections:Staff Publications

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