Please use this identifier to cite or link to this item: https://doi.org/10.1186/1471-2474-14-347
Title: Risk factors for incident hyperuricemia during mid-adulthood in African American and White men and women enrolled in the ARIC cohort study
Authors: McAdams-Demarco, M.A 
Law, A
Maynard, J.W
Coresh, J
Baer, A.N
Keywords: triacylglycerol
urate
adult
adulthood
African American
article
cohort analysis
demography
education
female
glomerulus filtration rate
human
hypertension
hyperuricemia
incidence
ischemic heart disease
major clinical study
male
middle aged
obesity
risk factor
smoking
triacylglycerol blood level
uric acid blood level
African Americans
Cohort Studies
European Continental Ancestry Group
Female
Humans
Hyperuricemia
Incidence
Male
Middle Aged
Prospective Studies
Risk Assessment
Risk Factors
United States
Uric Acid
Issue Date: 2013
Citation: McAdams-Demarco, M.A, Law, A, Maynard, J.W, Coresh, J, Baer, A.N (2013). Risk factors for incident hyperuricemia during mid-adulthood in African American and White men and women enrolled in the ARIC cohort study. BMC Musculoskeletal Disorders 14 : 347. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-2474-14-347
Rights: Attribution 4.0 International
Abstract: Background: Increased serum urate levels are associated with poor outcomes including but not limited to gout. It is unclear whether serum urate levels are the sole predictor of incident hyperuricemia or whether demographic and clinical risk factors also predict the development of hyperuricemia. The goal of this study was to identify risk factors for incident hyperuricemia over 9 years in a population-based study, ARIC. Methods. ARIC recruited individuals from 4 US communities; 8,342 participants who had urate levels <7.0 mg/dL were included in this analysis. Risk factors (including baseline, 3-year, and change in urate level over 3 years) for 9-year incident hyperuricemia (urate level of >7.0 g/dL) were identified using an AIC-based selection approach in a modified Poisson regression model. Results: The 9-year cumulative incidence of hyperuricemia was 4%; men = 5%; women = 3%; African Americans = 6% and whites = 3%. The adjusted model included 9 predictors for incident hyperuricemia over 9 years: male sex (RR = 1.73 95% CI: 1.36-2.21), African-American race (RR = 1.79 95% CI: 1.37-2.33), smoking (RR = 1.27, 95% CI: 0.97-1.67),
Source Title: BMC Musculoskeletal Disorders
URI: https://scholarbank.nus.edu.sg/handle/10635/181536
ISSN: 14712474
DOI: 10.1186/1471-2474-14-347
Rights: Attribution 4.0 International
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