Please use this identifier to cite or link to this item:
https://doi.org/10.1186/1471-230X-14-77
Title: | Correlation between depression, anxiety, and polymorphonuclear cells' resilience in ulcerative colitis: The mediating role of heat shock protein 70 | Authors: | Vlachos, I.I Barbatis, C Tsopanomichalou, M Abou-Assabeh, L Goumas, K Ginieri-Coccossis, M Economou, M Papadimitriou, G.N Patsouris, E Nicolopoulou-Stamati, P |
Keywords: | heat shock protein 70 heat shock protein 70 adult anxiety article clinical article colon biopsy controlled study cross-sectional study depression disease severity down regulation epithelium female Hospital Anxiety and Depression Scale human human cell human tissue immunohistochemistry immunoreactivity male polymorphonuclear cell protein expression protein induction psychological rating scale questionnaire Rachmilewitz Index scoring system Spielberg State Trait Anxiety Inventory ulcerative colitis Zung Depression Rating Scale aged anxiety colon depression metabolism middle aged neutrophil psychology severity of illness index statistical model ulcerative colitis Adult Aged Anxiety Colitis, Ulcerative Colon Cross-Sectional Studies Depression Female HSP70 Heat-Shock Proteins Humans Logistic Models Male Middle Aged Neutrophils Questionnaires Severity of Illness Index |
Issue Date: | 2014 | Citation: | Vlachos, I.I, Barbatis, C, Tsopanomichalou, M, Abou-Assabeh, L, Goumas, K, Ginieri-Coccossis, M, Economou, M, Papadimitriou, G.N, Patsouris, E, Nicolopoulou-Stamati, P (2014). Correlation between depression, anxiety, and polymorphonuclear cells' resilience in ulcerative colitis: The mediating role of heat shock protein 70. BMC Gastroenterology 14 (1) : 77. ScholarBank@NUS Repository. https://doi.org/10.1186/1471-230X-14-77 | Rights: | Attribution 4.0 International | Abstract: | Background: To investigate whether anxiety and depression levels are associated with Heat Shock Protein 70 (HSP70) induction in the colon of patients with ulcerative colitis (UC).Methods: The design was cross-sectional. Clinical activity was assessed by the Rachmilewitz Index (CAI). Three psychometric questionnaires were used: Zung Depression Rating Scale (ZDRS), Spielberg State-Trait Anxiety Inventory (STAI), Hospital Anxiety and Depression Scale (HADS). Colon biopsies were obtained from each affected anatomical site. Severity of inflammation was assessed by eosin/hematoxylin. Constitutive (HSP70c) and inducible (HSP70i) HSP70 expression were immunohistochemically studied.Results: 29 UC patients were enrolled (69% men). Mean age was 46.5 years (SD: 19.5). Inflammation severity was moderate in 17 patients, severe in 6, and mild in 6. The mean number of years since diagnosis was 7.9 (SD: 6.5). The mean CAI was 6.4 (SD: 3.1). In active UC, there was downregulation of HSP70c in inflamed epithelium, without significant HSP70 induction. In 22/29 cases of active cryptitis, polymorphonuclear cells (PMN) clearly expressed HSP70i, with weak, focal positivity in the other 7 cases. Except for the hospital anxiety scale, scores in all psychometric tools were higher in patients with strong HSP70i immunoreactivity in the PMN. Logistic regression showed a strong positive relationship between HSP70i immunoreactivity in the PMN cells and scores in the trait anxiety, ZDRS, and hospital depression scales, (Odds ratios 1.3, 1.3, and 1.5; P = 0.018, 0.023, and 0.038; Wald test, 5.6, 5.2, and 4.3 respectively) and a weaker but significant positive correlation with the CAI (Odds ratio 1.654; P = 0.049; Wald test 3.858).Conclusion: HSP70 is induced in PMN cells of UC patients and its induction correlates with depression and anxiety levels. © 2014 Vlachos et al.; licensee BioMed Central Ltd. | Source Title: | BMC Gastroenterology | URI: | https://scholarbank.nus.edu.sg/handle/10635/181504 | ISSN: | 1471230X | DOI: | 10.1186/1471-230X-14-77 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
Show full item record
Files in This Item:
File | Description | Size | Format | Access Settings | Version | |
---|---|---|---|---|---|---|
10_1186_1471-230X-14-77.pdf | 1.67 MB | Adobe PDF | OPEN | None | View/Download |
This item is licensed under a Creative Commons License