Please use this identifier to cite or link to this item: https://doi.org/10.3389/fnbeh.2014.00336
Title: Optogenetics reveals a role for accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization
Authors: Song, S.S
Kang, B.J
Lee, H.J
Sim, H.-R
Kim, T.H
Yoon, S
Yoon, B.-J
Baik, J.-H
Wen, L
Augustine, G.J 
Wen, L
Wen, L
Keywords: cocaine
dopamine 2 receptor
rhodopsin
virus vector
animal behavior
animal cell
animal experiment
Article
brain electrophysiology
cocaine dependence
confocal laser microscopy
controlled study
dopaminergic nerve cell
evoked inhibitory postsynaptic current
habituation
human
human cell
hyperpolarization
immunofluorescence
in vivo study
inhibitory postsynaptic potential
latent period
medium spiny nerve cell
membrane steady potential
mouse
nerve cell membrane steady potential
nonhuman
nucleus accumbens
optogenetics
phenotypic plasticity
photostimulation
protein expression
relapse
signal transduction
spinal cord nerve cell
withdrawal syndrome
Issue Date: 2014
Citation: Song, S.S, Kang, B.J, Lee, H.J, Sim, H.-R, Kim, T.H, Yoon, S, Yoon, B.-J, Baik, J.-H, Wen, L, Augustine, G.J, Wen, L, Wen, L (2014). Optogenetics reveals a role for accumbal medium spiny neurons expressing dopamine D2 receptors in cocaine-induced behavioral sensitization. Frontiers in Behavioral Neuroscience 8 (OCT) : 1-11. ScholarBank@NUS Repository. https://doi.org/10.3389/fnbeh.2014.00336
Rights: Attribution 4.0 International
Abstract: Long-lasting, drug-induced adaptations within the nucleus accumbens (NAc) have been proposed to contribute to drug-mediated addictive behaviors. Here we have used an optogenetic approach to examine the role of NAc medium spiny neurons (MSNs) expressing dopamine D2 receptors (D2Rs) in cocaine-induced behavioral sensitization. Adeno-associated viral vectors encoding channelrhodopsin-2 (ChR2) were delivered into the NAc of D2R-Cre transgenic mice. This allowed us to selectively photostimulate D2R-MSNs in NAc. D2R-MSNs form local inhibitory circuits, because photostimulation of D2R-MSN evoked inhibitory postsynaptic currents (IPSCs) in neighboring MSNs. Photostimulation of NAc D2R-MSN in vivo affected neither the initiation nor the expression of cocaine-induced behavioral sensitization. However, photostimulation during the drug withdrawal period attenuated expression of cocaine-induced behavioral sensitization. These results show that D2R-MSNs of NAc play a key role in withdrawal-induced plasticity and may contribute to relapse after cessation of drug abuse. © 2014 Song, Kang, Wen, Lee, Sim, Kim, Yoon, Yoon, Augustine and Baik.
Source Title: Frontiers in Behavioral Neuroscience
URI: https://scholarbank.nus.edu.sg/handle/10635/181482
ISSN: 16625153
DOI: 10.3389/fnbeh.2014.00336
Rights: Attribution 4.0 International
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