Please use this identifier to cite or link to this item: https://doi.org/10.1186/s12890-015-0089-9
Title: Radial endobronchial ultrasound in diagnosing peripheral lung lesions in a high tuberculosis setting
Authors: Chan, A
Devanand, A 
Low, S.Y 
Koh, M.S 
Keywords: tuberculostatic agent
adult
aged
Article
bronchoscope
bronchoscopy
computer assisted tomography
controlled study
diagnostic imaging equipment
diagnostic test accuracy study
early diagnosis
endobronchial ultrasonography
female
histopathology
human
human tissue
incidence
lung cancer
lung tuberculosis
major clinical study
male
monitor
peripheral lung lesion
post hoc analysis
predictive value
retrospective study
sensitivity and specificity
Singapore
complication
differential diagnosis
endoscopic ultrasonography
follow up
Lung Neoplasms
middle aged
procedures
reproducibility
Tuberculosis, Pulmonary
x-ray computed tomography
Aged
Bronchoscopy
Diagnosis, Differential
Endosonography
Female
Follow-Up Studies
Humans
Lung Neoplasms
Male
Middle Aged
Predictive Value of Tests
Reproducibility of Results
Retrospective Studies
Tomography, X-Ray Computed
Tuberculosis, Pulmonary
Issue Date: 2015
Citation: Chan, A, Devanand, A, Low, S.Y, Koh, M.S (2015). Radial endobronchial ultrasound in diagnosing peripheral lung lesions in a high tuberculosis setting. BMC Pulmonary Medicine 15 (1) : 90. ScholarBank@NUS Repository. https://doi.org/10.1186/s12890-015-0089-9
Rights: Attribution 4.0 International
Abstract: Background: Current data for the utility of radial endobronchial ultrasound (EBUS) in investigating peripheral lung lesions (PLLs) has been restricted to populations with low pulmonary tuberculosis (TB) incidence. The aim of this study was to assess the diagnostic utility of radial EBUS with guide sheath in the diagnosis of peripheral lung lesions in Singapore, a high TB incidence setting. Methods: A post-hoc database analysis was performed. 123 consecutive patients with computed tomographic evidence of PLLs who underwent radial EBUS guided bronchoscopy were included. Results: The final diagnosis was malignancy in 76 cases and benign in 44 cases. Radial EBUS guided bronchoscopy had a sensitivity of 65.8 % for malignancy, positive predictive value of 100 %, negative predictive value of 62.9 %, and a diagnostic accuracy of 82.5 %. 22 patients had a final diagnosis of pulmonary TB. The diagnostic sensitivity for pulmonary TB was 77.3 %, with a positive predictive value of 100 %, negative predictive value of 95.2 % and a diagnostic accuracy of 95.8 %. Overall, 58.8 % of pulmonary TB cases relied on histology to make an early diagnosis. Conclusion: Radial EBUS guided bronchosopy is useful in investigating PLLs in a high TB incidence setting. Our data also suggests that radial EBUS is a more rapid diagnosis technique for tuberculous lesions. © 2015 Chan et al.
Source Title: BMC Pulmonary Medicine
URI: https://scholarbank.nus.edu.sg/handle/10635/181435
ISSN: 14712466
DOI: 10.1186/s12890-015-0089-9
Rights: Attribution 4.0 International
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