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Title: Barriers and facilitators for clinical trial participation among diverse Asian patients with breast cancer: A qualitative study
Authors: Lee, G.E
Ow, M 
Lie, D 
Dent, R 
Keywords: adult
breast cancer
cancer patient
cancer staging
cancer therapy
clinical research
clinical trial (topic)
controlled study
cost effectiveness analysis
cultural anthropology
doctor patient relation
health care system
major clinical study
Malay (people)
middle aged
patient attitude
patient participation
qualitative research
research subject
social aspect
Asian continental ancestry group
Breast Neoplasms
information processing
patient selection
research subject
Asian Continental Ancestry Group
Breast Neoplasms
Focus Groups
Middle Aged
Patient Selection
Qualitative Research
Research Subjects
Issue Date: 2016
Citation: Lee, G.E, Ow, M, Lie, D, Dent, R (2016). Barriers and facilitators for clinical trial participation among diverse Asian patients with breast cancer: A qualitative study. BMC Women's Health 16 (1) : 43. ScholarBank@NUS Repository.
Rights: Attribution 4.0 International
Abstract: Background: Recruitment rates for cancer trials are low for racial/ethnic minorities. Little is known about factors influencing trial recruitment in Asian patients. Our aim is to examine the barriers and facilitators for participation in trials among multi-ethnic Asian women with breast cancer. Methods: We recruited a convenience sample from consecutive women seen at the National Cancer Centre. Two experienced bilingual (English and Chinese) moderators conducted focus groups to theme saturation. The question guide incorporated open-ended questions soliciting opinions about trial participation and knowledge. Women were first asked if they were willing, unwilling, or still open to participate in future trials. Sessions were audiotaped and transcribed. Transcripts were independently coded for emergent themes. Results: Sixteen of 103 women approached participated in five focus groups. Chinese, Malay, and Indian participants aged 29 to 69 represented different cancer stages. Five had no prior knowledge of trials. We identified three major themes comprising of 22 minor themes for barriers and facilitators. The major themes were: 1) patient-related, 2) trial-related, and 3) sociocultural factors. Women willing to join trials expressed themes representing facilitators (better test therapy, cost-effective profile, or trust in doctors and local healthcare systems). Women unwilling to participate expressed themes associated with barriers, while women still open to participation expressed themes representing both facilitators and barriers. Malay women were more likely to express themes related to 'fatalism' as a barrier. Discussion/Conclusion: We found that facilitators and barriers to trial participation among Asian women were similar to those previously reported in Western women. Knowledge of trials is limited among women receiving breast cancer treatment. Unique sociocultural factors suggest that approaches customised to local and community beliefs are needed to improve trial participation in minority groups. © 2016 The Author(s).
Source Title: BMC Women's Health
ISSN: 14726874
DOI: 10.1186/s12905-016-0319-1
Rights: Attribution 4.0 International
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