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https://doi.org/10.3389/fnsyn.2016.00020
Title: | The emergence of NMDA receptor metabotropic function: Insights from imaging | Authors: | Dore, K Aow, J Malinow, R |
Keywords: | amyloid beta protein ionotropic receptor metabotropic receptor n methyl dextro aspartic acid receptor Article cerebrovascular accident human ion transport learning ligand binding long term depression long term potentiation memory nerve cell necrosis nerve conduction nervous system electrophysiology neuroimaging neurologic disease neuromodulation neurophysiology nonhuman physiological process protein determination protein domain protein function protein transport signal transduction synaptic transmission |
Issue Date: | 2016 | Citation: | Dore, K, Aow, J, Malinow, R (2016). The emergence of NMDA receptor metabotropic function: Insights from imaging. Frontiers in Synaptic Neuroscience 8 : 20. ScholarBank@NUS Repository. https://doi.org/10.3389/fnsyn.2016.00020 | Rights: | Attribution 4.0 International | Abstract: | The NMDA receptor (R) participates in many important physiological and pathologicalprocesses. For example, its activation is required for both long-term potentiation (LTP)and long-term depression (LTD) of synaptic transmission, cellular models of learning andmemory. Furthermore, it may play a role in the actions of amyloid-beta on synapsesas well as in the signaling leading to cell death following stroke. Until recently, theseprocesses were thought to be mediated by ion-flux through the receptor. Using acombination of imaging and electrophysiological approaches, ion-flux independentfunctions of the NMDAR were recently examined. In this review, we will discuss therole of metabotropic NMDAR function in LTD and synaptic dysfunction. © 2016 Dore. | Source Title: | Frontiers in Synaptic Neuroscience | URI: | https://scholarbank.nus.edu.sg/handle/10635/181352 | ISSN: | 16633563 | DOI: | 10.3389/fnsyn.2016.00020 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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