Please use this identifier to cite or link to this item:
https://doi.org/10.3389/fnsyn.2016.00020
DC Field | Value | |
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dc.title | The emergence of NMDA receptor metabotropic function: Insights from imaging | |
dc.contributor.author | Dore, K | |
dc.contributor.author | Aow, J | |
dc.contributor.author | Malinow, R | |
dc.date.accessioned | 2020-10-27T10:39:46Z | |
dc.date.available | 2020-10-27T10:39:46Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Dore, K, Aow, J, Malinow, R (2016). The emergence of NMDA receptor metabotropic function: Insights from imaging. Frontiers in Synaptic Neuroscience 8 : 20. ScholarBank@NUS Repository. https://doi.org/10.3389/fnsyn.2016.00020 | |
dc.identifier.issn | 16633563 | |
dc.identifier.uri | https://scholarbank.nus.edu.sg/handle/10635/181352 | |
dc.description.abstract | The NMDA receptor (R) participates in many important physiological and pathologicalprocesses. For example, its activation is required for both long-term potentiation (LTP)and long-term depression (LTD) of synaptic transmission, cellular models of learning andmemory. Furthermore, it may play a role in the actions of amyloid-beta on synapsesas well as in the signaling leading to cell death following stroke. Until recently, theseprocesses were thought to be mediated by ion-flux through the receptor. Using acombination of imaging and electrophysiological approaches, ion-flux independentfunctions of the NMDAR were recently examined. In this review, we will discuss therole of metabotropic NMDAR function in LTD and synaptic dysfunction. © 2016 Dore. | |
dc.rights | Attribution 4.0 International | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.source | Unpaywall 20201031 | |
dc.subject | amyloid beta protein | |
dc.subject | ionotropic receptor | |
dc.subject | metabotropic receptor | |
dc.subject | n methyl dextro aspartic acid receptor | |
dc.subject | Article | |
dc.subject | cerebrovascular accident | |
dc.subject | human | |
dc.subject | ion transport | |
dc.subject | learning | |
dc.subject | ligand binding | |
dc.subject | long term depression | |
dc.subject | long term potentiation | |
dc.subject | memory | |
dc.subject | nerve cell necrosis | |
dc.subject | nerve conduction | |
dc.subject | nervous system electrophysiology | |
dc.subject | neuroimaging | |
dc.subject | neurologic disease | |
dc.subject | neuromodulation | |
dc.subject | neurophysiology | |
dc.subject | nonhuman | |
dc.subject | physiological process | |
dc.subject | protein determination | |
dc.subject | protein domain | |
dc.subject | protein function | |
dc.subject | protein transport | |
dc.subject | signal transduction | |
dc.subject | synaptic transmission | |
dc.type | Article | |
dc.contributor.department | MEDICINE | |
dc.description.doi | 10.3389/fnsyn.2016.00020 | |
dc.description.sourcetitle | Frontiers in Synaptic Neuroscience | |
dc.description.volume | 8 | |
dc.description.page | 20 | |
Appears in Collections: | Elements Staff Publications |
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