Please use this identifier to cite or link to this item: https://doi.org/10.1002/adfm.201700523
Title: Distinct Bimodal Roles of Aromatic Molecules in Controlling Gold Nanorod Growth for Biosensing
Authors: Soh, J.H
Lin, Y
Thomas, M.R
Todorova, N
Kallepitis, C
Yarovsky, I
Ying, J.Y 
Stevens, M.M
Keywords: Alkalinity
Aromatic compounds
Aromatization
Aspect ratio
Binding energy
Bins
Medical applications
Molecules
Nanorods
Phosphatases
Plasmons
Redox reactions
Surface plasmon resonance
Synthesis (chemical)
ALkaline phosphatase
Anisotropic growth
Aromatic additives
Gold nanorod
Plasmonic sensing
Gold
Issue Date: 2017
Citation: Soh, J.H, Lin, Y, Thomas, M.R, Todorova, N, Kallepitis, C, Yarovsky, I, Ying, J.Y, Stevens, M.M (2017). Distinct Bimodal Roles of Aromatic Molecules in Controlling Gold Nanorod Growth for Biosensing. Advanced Functional Materials 27 (29) : 1700523. ScholarBank@NUS Repository. https://doi.org/10.1002/adfm.201700523
Rights: Attribution 4.0 International
Abstract: New aromatic molecule–seed particle interactions are examined and exploited to control and guide seed-mediated gold nanorod (Au NR) growth. This new approach enables better understanding of how small molecules impact the synthesis of metallic nanostructures, catalyzing their use in various biomedical applications, such as plasmonic biosensing. Experimental studies and theoretical molecular simulations using a library of aromatic molecules, making use of the chemical versatility of the molecules with varied spatial arrangements of electron-donating/withdrawing groups, charge, and Au-binding propensity, are performed. Au NR growth is regulated by two principal mechanisms, producing either a red or blue shift in the longitudinal localized surface plasmon resonance (LLSPR) peaks. Aromatic molecules with high redox potentials produce an increase in NR aspect ratio and red shift of LLSPR peaks. In contrast, molecules that strongly bind gold surfaces result in blue shifts, demonstrating a strong correlation between their binding energy and blue shifts produced. Through enzymatic conversion of selected molecules, 4-aminophenylphosphate to 4-aminophenol, opposing growth mechanisms at opposite extremes of target concentration are obtained, and a chemical pathway for performing plasmonic enzyme-linked immunosorbent assays is established. This unlocks new strategies for tailoring substrate design and enzymatic mechanisms for controlling plasmonic response to target molecules in biosensing applications. © 2017 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Source Title: Advanced Functional Materials
URI: https://scholarbank.nus.edu.sg/handle/10635/181257
ISSN: 1616301X
DOI: 10.1002/adfm.201700523
Rights: Attribution 4.0 International
Appears in Collections:Elements
Staff Publications

Show full item record
Files in This Item:
File Description SizeFormatAccess SettingsVersion 
10_1002_adfm_201700523.pdf1.74 MBAdobe PDF

OPEN

NoneView/Download

Google ScholarTM

Check

Altmetric


This item is licensed under a Creative Commons License Creative Commons