Please use this identifier to cite or link to this item: https://doi.org/10.3390/md15120352
Title: Liposomal circular dichroism (L-Cd) of arenoyl derivatives of sphingolipids. Amplification of cotton effects in ordered lipid bilayers
Authors: Molinski, T.F
Broaddus, C.D
Morinaka, B.I 
Keywords: aminoalcohol
arenoyl derivative
liposome
n, O,O' tri (6' methoxy 2' naphthoyl) dextro erythro sphingosine
sphinganine
sphingolipid
sphingosine
unclassified drug
carboxylic acid
liposome
sphingolipid
Article
chemical analysis
chemical structure
circular dichroism
lipid bilayer
molecular interaction
synthesis
analogs and derivatives
chemistry
circular dichroism
lipid bilayer
procedures
stereoisomerism
Acids, Acyclic
Circular Dichroism
Lipid Bilayers
Liposomes
Sphingolipids
Sphingosine
Stereoisomerism
Issue Date: 2017
Citation: Molinski, T.F, Broaddus, C.D, Morinaka, B.I (2017). Liposomal circular dichroism (L-Cd) of arenoyl derivatives of sphingolipids. Amplification of cotton effects in ordered lipid bilayers. Marine Drugs 15 (12) : 352. ScholarBank@NUS Repository. https://doi.org/10.3390/md15120352
Rights: Attribution 4.0 International
Abstract: Liposomal circular dichroism (L-CD) of acyclic amino alcohols exhibit amplification of Cotton effects when measured in highly uniform, unilamellar liposomes. The effect is likely due to intermolecular associations—H-aggregates—that self-assemble spontaneously within the lipid bilayer, and persists over long time scales. L-CD spectra of N,O,O-tri-(6′methoxy-2′naphthoyl)-D-erythro-sphingosine, or the corresponding dihydro-derivative (sphinganine), shows ~10-fold amplification of magnitudes of Cotton effects over conventional CD spectra recorded in isotropic solution. © 2017 by the authors.
Source Title: Marine Drugs
URI: https://scholarbank.nus.edu.sg/handle/10635/181233
ISSN: 16603397
DOI: 10.3390/md15120352
Rights: Attribution 4.0 International
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