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Title: | Liposomal circular dichroism (L-Cd) of arenoyl derivatives of sphingolipids. Amplification of cotton effects in ordered lipid bilayers | Authors: | Molinski, T.F Broaddus, C.D Morinaka, B.I |
Keywords: | aminoalcohol arenoyl derivative liposome n, O,O' tri (6' methoxy 2' naphthoyl) dextro erythro sphingosine sphinganine sphingolipid sphingosine unclassified drug carboxylic acid liposome sphingolipid Article chemical analysis chemical structure circular dichroism lipid bilayer molecular interaction synthesis analogs and derivatives chemistry circular dichroism lipid bilayer procedures stereoisomerism Acids, Acyclic Circular Dichroism Lipid Bilayers Liposomes Sphingolipids Sphingosine Stereoisomerism |
Issue Date: | 2017 | Citation: | Molinski, T.F, Broaddus, C.D, Morinaka, B.I (2017). Liposomal circular dichroism (L-Cd) of arenoyl derivatives of sphingolipids. Amplification of cotton effects in ordered lipid bilayers. Marine Drugs 15 (12) : 352. ScholarBank@NUS Repository. https://doi.org/10.3390/md15120352 | Rights: | Attribution 4.0 International | Abstract: | Liposomal circular dichroism (L-CD) of acyclic amino alcohols exhibit amplification of Cotton effects when measured in highly uniform, unilamellar liposomes. The effect is likely due to intermolecular associations—H-aggregates—that self-assemble spontaneously within the lipid bilayer, and persists over long time scales. L-CD spectra of N,O,O-tri-(6′methoxy-2′naphthoyl)-D-erythro-sphingosine, or the corresponding dihydro-derivative (sphinganine), shows ~10-fold amplification of magnitudes of Cotton effects over conventional CD spectra recorded in isotropic solution. © 2017 by the authors. | Source Title: | Marine Drugs | URI: | https://scholarbank.nus.edu.sg/handle/10635/181233 | ISSN: | 16603397 | DOI: | 10.3390/md15120352 | Rights: | Attribution 4.0 International |
Appears in Collections: | Elements Staff Publications |
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